Concepedia

Maximum Tolerated Dose Modeling

Maximum Tolerated Dose Modeling is a pharmacostatistical methodology that identifies the highest dose of a therapeutic agent associated with an acceptable level of toxicity within a population, distinguishing it from other dose-finding approaches by focusing on the upper limit of tolerable exposure in the context of exposure-response relationships.

97

Publications

7K

Citations

521

Authors

236

Institutions

Publications per year

2017–2026

19

Parents

Publications

97

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use

Sebastian J. Padayatty, He Sun, Yaohui Wang et al. · Annals of Internal Medicine · 2004 · 967 citations

, , +11

Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors

Johanna C. Bendell, Jordi Rodón, Howard A. Burris et al. · Journal of Clinical Oncology · 2011 · 686 citations · Full text

, , +14

Cancer phase I clinical trials: efficient dose escalation with overdose control

James S. Babb, André Rogatko, Shelemyahu Zacks · Statistics in Medicine · 1998 · 621 citations

, , +17

Bayesian optimal interval designs for phase I clinical trials

Suyu Liu, Ying Yuan · Journal of the Royal Statistical Society Series C (Applied Statistics) · 2014 · 344 citations

, , +14

Practical modifications of the continual reassessment method for phase i cancer clinical trials

Douglas E. Faries · Journal of Biopharmaceutical Statistics · 1994 · 237 citations

, , +16

1–5 of 97

Authors

521

  1. AR
    André Rogatko

    Fox Chase Cancer Center, United States

    5 publications · 861 citations

    5

    h-index

  2. YY
    Ying Yuan

    The University of Texas MD Anderson Cancer Center, United States

    4 publications · 471 citations

    4

    h-index

  3. PG
    Per G. Söderberg

    Karolinska Institutet, Sweden

    4 publications · 66 citations

    4

    h-index

  4. MT
    Mourad Tighiouart

    Emory University, United States

    4 publications · 175 citations

    4

    h-index

  5. JS
    James S. Babb

    New York University, United States

    3 publications · 802 citations

    3

    h-index

1–5 of 521

Institutions

236

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    8 h-index

    19 publications

    1.3K citations

  2. Memorial Sloan Kettering Cancer Center

    New York, United States

    8 h-index

    21 publications

    643 citations

  3. University of Michigan

    Ann Arbor, United States

    5 h-index

    14 publications

    415 citations

  4. Karolinska Institutet

    Stockholm, Sweden

    4 h-index

    15 publications

    255 citations

  5. United States Food and Drug Administration

    Silver Spring, United States

    4 h-index

    13 publications

    7.9K citations

  6. Sorbonne Université

    Paris, France

    4 h-index

    13 publications

    390 citations

  7. Novartis (Switzerland)

    Basel, Switzerland

    4 h-index

    12 publications

    489 citations

  8. Fox Chase Cancer Center

    Philadelphia, United States

    4 h-index

    16 publications

    1.7K citations

1–8 of 236

Venues

  1. Journal of Clinical Oncology

    14 publications · 1.4K citations

    13

    h-index

  2. Statistics in Medicine

    11 publications · 1.1K citations

    11

    h-index

  3. Regulatory Toxicology and Pharmacology

    RTP · 4 publications · 144 citations

    4

    h-index

  4. Investigational New Drugs

    3 publications · 45 citations

    3

    h-index

  5. Journal of Biopharmaceutical Statistics

    JBS · 3 publications · 290 citations

    3

    h-index

1–5