Concepedia

Masked Functional Groups

Masked Functional Groups is a prodrug design strategy in which biologically active but potentially toxic functional groups are temporarily modified through chemical derivatization to reduce reactivity or toxicity, thereby improving pharmacokinetic properties and enabling controlled activation in vivo.

60

Publications

2.7K

Citations

249

Authors

104

Institutions

Publications per year

2017–2026

16

Parents

Publications

60

Protecting Group Strategies in Organic Synthesis

Michael Schelhaas, Herbert Waldmann · Angewandte Chemie International Edition in English · 1996 · 328 citations

, , +8

The phenyldimethylsilyl group as a masked hydroxy group

Ian Fleming, Rolf Henning, David C. Parker et al. · Journal of the Chemical Society Perkin Transactions 1 · 1995 · 240 citations

, , +12

Chemical Protein Synthesis with the α-Ketoacid–Hydroxylamine Ligation

Jeffrey W. Bode · Accounts of Chemical Research · 2017 · 185 citations · Full text

, , +12

<i>N</i><sup>α</sup>-2-Mercaptobenzylamine-Assisted Chemical Ligation

John Offer, Philip E. Dawson · Organic Letters · 1999 · 106 citations

, , +12

Bird traits in urban–rural gradients: how many functional groups are there?

Lucas M. Leveau · Journal für Ornithologie · 2013 · 99 citations · Full text

, , +12

1–5 of 60

Authors

249

  1. JW
    Jeffrey W. Bode

    ETH Zurich, Switzerland

    2 publications · 217 citations

    2

    h-index

  2. LV
    Loredana Valenzano

    Michigan Technological University, United States

    1 publications · 36 citations

    1

    h-index

  3. BM
    Bruce M. Cohen

    McLean Hospital, United States

    1 publications · 68 citations

    1

    h-index

  4. SV
    S. V. Lonikar

    Solapur University, India

    1 publications · 19 citations

    1

    h-index

  5. TD
    Tony D. James

    University of Bath, United Kingdom

    1 publications · 15 citations

    1

    h-index

1–5 of 249

Institutions

104

  1. Scripps Research Institute

    San Diego, United States

    2 h-index

    7 publications

    427 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    14 publications

    312 citations

  3. ETH Zurich

    Zurich, Switzerland

    2 h-index

    5 publications

    313 citations

  4. National Research Council

    Rome, Italy

    2 h-index

    6 publications

    177 citations

  5. Northeast Forestry University

    Harbin, China

    1 h-index

    3 publications

    57 citations

  6. McLean Hospital

    Belmont, United States

    1 h-index

    5 publications

    340 citations

  7. Central European Institute of Technology – Masaryk University

    Brno, Czechia

    1 h-index

    3 publications

    93 citations

  8. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    1 h-index

    2 publications

    152 citations

1–8 of 104

Venues

  1. The Journal of Organic Chemistry

    JOC · 7 publications · 177 citations

    7

    h-index

  2. Organic Letters

    OL · 5 publications · 256 citations

    5

    h-index

  3. Journal of the American Chemical Society

    JACS · 4 publications · 220 citations

    4

    h-index

  4. Chemical Communications

    ChemComm · 3 publications · 107 citations

    3

    h-index

  5. 2

    h-index

1–5