Concepedia

Marine-derived Lead Optimization

Marine-Derived Lead Optimization is the systematic refinement of bioactive compounds isolated from marine organisms to enhance their pharmacological efficacy, selectivity, and drug-like properties while preserving their unique structural scaffolds of marine origin.

6

Publications

165

Citations

26

Authors

9

Institutions

Publications per year

2017–2026

1

Parents

Publications

6

The marine natural-derived inhibitors of glycogen synthase kinase-3β phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling

Mohammad A. Khanfar, Bilal Abu Asal, Mudit Mudit et al. · Bioorganic & Medicinal Chemistry · 2009 · 53 citations · Full text

, , +15

Chemical Prospectors Scour the Seas for Promising Drugs

Faye Flam · Science · 1994 · 42 citations

, , +14

Marine Natural Products. Key Advances to the Practical Application of this Resource in Drug Development

Mark T. Hamann, Russell T. Hill, Silvio Roggo · CHIMIA International Journal for Chemistry · 2007 · 21 citations · Full text

, , +17

Natural Product-Based 6-Hydroxy-2,3,4,6-tetrahydropyrrolo[1,2-<i>a</i>]pyrimidinium Scaffold as a New Antifungal Template

Xing‐Cong Li, K. Suresh Babu, Melissa R. Jacob et al. · ACS Medicinal Chemistry Letters · 2011 · 21 citations

, , +17

Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β

Shuwen Han, Chunlin Zhuang, Wei Zhou et al. · Marine Drugs · 2021 · 17 citations · Full text

, , +17

1–5 of 6

Authors

26

  1. AK
    Ameeta K. Agarwal

    University of Mississippi, United States

    1 publications · 21 citations

    1

    h-index

  2. SI
    Shabana I. Khan

    University of Mississippi, United States

    1 publications · 21 citations

    1

    h-index

  3. RT
    Russell T. Hill

    University of Maryland, Baltimore, United States

    1 publications · 21 citations

    1

    h-index

  4. AK
    Amal Kaddoumi

    University of Louisiana at Monroe, United States

    1 publications · 53 citations

    1

    h-index

  5. BP
    Boris Pinchuk

    Christian-Albrechts-Universität zu Kiel, Germany

    1 publications · 11 citations

    1

    h-index

1–5 of 26

Institutions

9

  1. University of Mississippi

    Oxford, United States

    2 h-index

    7 publications

    147 citations

  2. Novartis (Switzerland)

    Basel, Switzerland

    1 h-index

    1 publications

    21 citations

  3. University of Louisiana at Monroe

    Monroe, United States

    1 h-index

    5 publications

    265 citations

  4. Biotechnology Institute

    Washington D.C., United States

    1 h-index

    1 publications

    21 citations

  5. University of Maryland, Baltimore

    Baltimore, United States

    1 h-index

    2 publications

    42 citations

  6. Institute of Marine Biotechnology

    Greifswald, Germany

    1 h-index

    1 publications

    21 citations

  7. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    1 h-index

    4 publications

    44 citations

  8. Triton Systems (United States)

    Chelmsford, United States

    1 h-index

    1 publications

    21 citations

1–8 of 9

Venues

  1. Marine Drugs

    2 publications · 28 citations

    2

    h-index

  2. CHIMIA International Journal for Chemistry

    1 publications · 21 citations

    1

    h-index

  3. Bioorganic & Medicinal Chemistry

    1 publications · 53 citations

    1

    h-index

  4. Science

    1 publications · 42 citations

    1

    h-index

  5. ACS Medicinal Chemistry Letters

    1 publications · 21 citations

    1

    h-index

1–5