Concepedia

Lytic-latent Switch

The "Lytic-Latent Switch" is a regulatory mechanism in viral latency that governs the transition between the lytic cycle, characterized by active viral replication and host cell destruction, and the latent cycle, marked by viral genome persistence with minimal gene expression and no immediate progeny production.

95

Publications

5.9K

Citations

397

Authors

158

Institutions

Publications per year

2017–2026

25

Variants

Lytic-lysogenic Switch

Parents

Publications

95

The Epstein–Barr virus lytic program is controlled by the co‐operative functions of two transactivators

Regina Feederle, Manuela Kost, Matthias Baumann et al. · The EMBO Journal · 2000 · 388 citations · Full text

, , +9

The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jκ (CSL), the target of the Notch signaling pathway

Yuying Liang, Jean Chang, Stephen J. Lynch et al. · Genes & Development · 2002 · 252 citations · Full text

, , +17

Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1

Erik K. Flemington, Samuel H. Speck · Journal of Virology · 1990 · 248 citations · Full text

, , +12

Epstein-Barr viral latency is disrupted by the immediate-early BRLF1 protein through a cell-specific mechanism.

S Zalani, Elizabeth Holley-Guthrie, Shannon C. Kenney · Proceedings of the National Academy of Sciences · 1996 · 224 citations

, , +17

Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: a Potential Mechanism for Virus-Mediated Control of Latency

Ke Lan, Daniel A. Kuppers, Subhash C. Verma et al. · Journal of Virology · 2004 · 209 citations · Full text

, , +15

1–5 of 95

Authors

397

  1. SC
    Shannon C. Kenney

    University of North Carolina at Chapel Hill, United States

    9 publications · 697 citations

    9

    h-index

  2. GM
    George Miller

    Yale University, United States

    9 publications · 397 citations

    9

    h-index

  3. JE
    Janet E. Mertz

    University of Wisconsin–Madison, United States

    7 publications · 481 citations

    7

    h-index

  4. AE
    Ayman El‐Guindy

    Yale University, United States

    6 publications · 242 citations

    6

    h-index

  5. SB
    Sumita Bhaduri‐McIntosh

    Stony Brook University, United States

    5 publications · 199 citations

    5

    h-index

1–5 of 397

Institutions

158

  1. University of Wisconsin–Madison

    Madison, United States

    13 h-index

    44 publications

    2.3K citations

  2. Yale University

    New Haven, United States

    10 h-index

    21 publications

    842 citations

  3. Harvard University

    Cambridge, United States

    6 h-index

    25 publications

    1.3K citations

  4. Pediatrics and Genetics

    Alpharetta, United States

    5 h-index

    18 publications

    720 citations

  5. Cincinnati Children's Hospital Medical Center

    Cincinnati, United States

    4 h-index

    4 publications

    291 citations

  6. Chang Gung University

    Taoyuan City, Taiwan

    3 h-index

    15 publications

    369 citations

  7. University of Cincinnati

    Cincinnati, United States

    3 h-index

    3 publications

    270 citations

  8. UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, United States

    3 h-index

    9 publications

    571 citations

1–8 of 158

Venues

  1. Journal of Virology

    JVI · 50 publications · 3.2K citations

    35

    h-index

  2. PLoS Pathogens

    9 publications · 526 citations

    8

    h-index

  3. Journal of General Virology

    6 publications · 195 citations

    6

    h-index

  4. Frontiers in Microbiology

    4 publications · 181 citations

    4

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 387 citations

    2

    h-index

1–5