Concepedia

Lysosome Acidification

Lysosome Acidification is the process by which the lysosomal lumen achieves and maintains an acidic internal pH through the active transport of protons via vacuolar-type H⁺-ATPase pumps, distinguishing it from other organelle acidification mechanisms by its specificity to lysosomal function and membrane dynamics.

144

Publications

16.3K

Citations

660

Authors

226

Institutions

Publications per year

2017–2026

34

Parents

Publications

144

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

Tamotsu Yoshimori, Akira Yamamoto, Yoshinori Moriyama et al. · Journal of Biological Chemistry · 1991 · 1.4K citations · Full text

, , +14

Lack of Acidification in <i>Mycobacterium</i> Phagosomes Produced by Exclusion of the Vesicular Proton-ATPase

Sheila Sturgill-Koszycki, Paul H. Schlesinger, Prasanta Chakraborty et al. · Science · 1994 · 1.3K citations

, , +16

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

Roland Baron, Lynn Neff, Daniel Louvard et al. · The Journal of Cell Biology · 1985 · 736 citations · Full text

, , +17

The position of lysosomes within the cell determines their luminal pH

Danielle Johnson, Philip P. Ostrowski, Valentin Jaumouillé et al. · The Journal of Cell Biology · 2016 · 607 citations · Full text

, , +17

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

Caroline Mauvezin, Péter Nagy, Gábor Juhász et al. · Nature Communications · 2015 · 436 citations · Full text

, , +15

1–5 of 144

Authors

660

  1. SG
    Sergio Grinstein

    Hospital for Sick Children, Canada

    7 publications · 1.2K citations

    7

    h-index

  2. YM
    Yoshinori Moriyama

    Okayama University, Japan

    6 publications · 2K citations

    6

    h-index

  3. AK
    Agnes K. Fok

    University of Hawaii System, United States

    4 publications · 1.4K citations

    4

    h-index

  4. RD
    Richard D. Allen

    University of Hawaii System, United States

    4 publications · 1.4K citations

    4

    h-index

  5. TJ
    Thomas J. Jentsch

    Universität Hamburg, Germany

    4 publications · 469 citations

    4

    h-index

1–5 of 660

Institutions

226

  1. Hospital for Sick Children

    Toronto, Canada

    8 h-index

    30 publications

    4.9K citations

  2. University of Toronto

    Toronto, Canada

    6 h-index

    21 publications

    1.9K citations

  3. University of Michigan

    Ann Arbor, United States

    5 h-index

    33 publications

    4K citations

  4. University of California, Los Angeles

    Los Angeles, United States

    5 h-index

    8 publications

    433 citations

  5. The University of Texas Southwestern Medical Center

    Dallas, United States

    4 h-index

    11 publications

    1.9K citations

  6. Cornell University

    Ithaca, United States

    4 h-index

    15 publications

    1.1K citations

  7. Washington University in St. Louis

    St Louis, United States

    4 h-index

    16 publications

    11.3K citations

  8. University of Hawaii System

    Honolulu, United States

    4 h-index

    11 publications

    2.9K citations

1–8 of 226

Venues

  1. The Journal of Cell Biology

    JCB · 18 publications · 3.6K citations

    18

    h-index

  2. Journal of Biological Chemistry

    JBC · 14 publications · 3K citations

    14

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 1K citations

    6

    h-index

  4. Biochemical and Biophysical Research Communications

    BBRC · 5 publications · 166 citations

    5

    h-index

  5. Journal of Cell Science

    5 publications · 350 citations

    5

    h-index

1–5