Concepedia

Loss Of Response

Loss of Response is a pharmacotherapeutic phenomenon in which a patient with Crohn disease initially demonstrates clinical improvement to a biologic agent but subsequently experiences a diminished therapeutic effect despite continued treatment at the same dose and regimen.

309

Publications

26.2K

Citations

2.1K

Authors

766

Institutions

Publications per year

2017–2026

105

Parents

Publications

309

Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial

Jean–Frédéric Colombel, William J. Sandborn, Paul Rutgeerts et al. · Gastroenterology · 2006 · 2.3K citations · Full text

, , +16

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

William J. Sandborn, Christopher Gasink, Long-Long Gao et al. · New England Journal of Medicine · 2012 · 1.1K citations

, , +17

Adalimumab Induction Therapy for Crohn Disease Previously Treated with Infliximab

William J. Sandborn, Paul Rutgeerts, Robert Enns et al. · Annals of Internal Medicine · 2007 · 960 citations

, , +17

Loss of Response to Anti-TNFs: Definition, Epidemiology, and Management

Giulia Roda, Bindia Jharap, Neeraj Narula et al. · Clinical and Translational Gastroenterology · 2016 · 713 citations · Full text

, , +17

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Nicholas A. Kennedy, Graham Heap, Harry Green et al. · ˜The œLancet. Gastroenterology & hepatology · 2019 · 677 citations · Full text

, , +17

1–5 of 309

Authors

2.1K

  1. WJ
    William J. Sandborn

    University of California San Diego, United States

    33 publications · 7.2K citations

    25

    h-index

  2. GD
    Geert D’Haens

    Amsterdam UMC Location University of Amsterdam, Netherlands

    21 publications · 3.5K citations

    19

    h-index

  3. SV
    Séverine Vermeire

    KU Leuven, Belgium

    21 publications · 3.3K citations

    17

    h-index

  4. RP
    Remo Panaccione

    University of Calgary, Canada

    17 publications · 5.9K citations

    16

    h-index

  5. PR
    Paul Rutgeerts

    KU Leuven, Belgium

    17 publications · 6.7K citations

    14

    h-index

1–5 of 2.1K

Institutions

766

  1. Icahn School of Medicine at Mount Sinai

    New York, United States

    20 h-index

    42 publications

    7.8K citations

  2. Inserm

    Paris, France

    18 h-index

    60 publications

    5.8K citations

  3. KU Leuven

    Leuven, Belgium

    16 h-index

    58 publications

    8.7K citations

  4. University of California San Diego

    San Diego, United States

    16 h-index

    27 publications

    3.4K citations

  5. University of Calgary

    Calgary, Canada

    14 h-index

    49 publications

    19.7K citations

  6. Hôpital Saint-Louis

    Paris, France

    13 h-index

    44 publications

    5.3K citations

  7. Mayo Clinic

    Rochester, United States

    13 h-index

    43 publications

    16.9K citations

  8. Université Paris Cité

    Paris, France

    13 h-index

    34 publications

    5.2K citations

1–8 of 766

Venues

  1. Alimentary Pharmacology & Therapeutics

    34 publications · 2.3K citations

    28

    h-index

  2. Inflammatory Bowel Diseases

    30 publications · 2.1K citations

    26

    h-index

  3. Clinical Gastroenterology and Hepatology

    CGH · 22 publications · 2.2K citations

    21

    h-index

  4. Journal of Crohn s and Colitis

    JCC · 29 publications · 1.6K citations

    20

    h-index

  5. Gastroenterology

    31 publications · 5.4K citations

    19

    h-index

1–5