Concepedia

Locus-specific Transgene Integration

Locus-Specific Transgene Integration is a gene knock-in strategy that integrates a transgene into a precise genomic locus through targeted homologous recombination or site-specific nucleases, thereby ensuring predictable transgene expression and minimizing positional effects compared to random integration methods.

61

Publications

3.3K

Citations

317

Authors

130

Institutions

Publications per year

2017–2026

6

Parents

Publications

61

Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter.

Chihiro Hama, Zehra Ali, Thomas B. Kornberg · Genes & Development · 1990 · 243 citations · Full text

, , +17

Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.

John Strouboulis, Niall Dillon, F. Grosveld · Genes & Development · 1992 · 215 citations · Full text

, , +15

Single-copy transgenic wheat generated through the resolution of complex integration patterns

Vibha Srivastava, Olin D. Anderson, David W. Ow · Proceedings of the National Academy of Sciences · 1999 · 198 citations

, , +17

In vivo cleavage of transgene donors promotes nuclease‐mediated targeted integration

Sandra Cristea, Yevgeniy Freyvert, Yolanda Santiago et al. · Biotechnology and Bioengineering · 2012 · 179 citations

, , +15

Targeted integration into a rRNA locus results in uniform and high level expression of transgenes in Leishmania amastigotes

Jeremy C. Mottram, Peter Overath, Toni Aebischer · Molecular and Biochemical Parasitology · 2000 · 151 citations

, , +13

1–5 of 61

Authors

317

  1. VS
    Vibha Srivastava

    University of Arkansas at Fayetteville, United States

    3 publications · 314 citations

    3

    h-index

  2. ND
    Niall Dillon

    Hammersmith Hospital, United Kingdom

    2 publications · 266 citations

    2

    h-index

  3. GZ
    Guoan Zhang

    New York University, United States

    1 publications · 57 citations

    1

    h-index

  4. RK
    Ryan Kuzmickas

    Harvard University, United States

    1 publications · 73 citations

    1

    h-index

  5. GD
    G.R. Douglas

    Health Canada, Canada

    1 publications · 29 citations

    1

    h-index

1–5 of 317

Institutions

130

  1. International Rice Research Institute

    Los Baños, Philippines

    2 h-index

    9 publications

    389 citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    2 h-index

    2 publications

    50 citations

  3. University of Arkansas at Fayetteville

    Fayetteville, United States

    2 h-index

    7 publications

    460 citations

  4. Western University

    London, Canada

    2 h-index

    7 publications

    212 citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    7 publications

    108 citations

  6. Wellcome Centre for Molecular Parasitology

    Glasgow, United Kingdom

    1 h-index

    1 publications

    151 citations

  7. Dayeh University

    Dacun, Taiwan

    1 h-index

    1 publications

    10 citations

  8. Center for Cancer Research

    Bethesda, United States

    1 h-index

    3 publications

    51 citations

1–8 of 130

Venues

  1. Virology

    3 publications · 91 citations

    3

    h-index

  2. Nucleic Acids Research

    3 publications · 213 citations

    3

    h-index

  3. Scientific Reports

    3 publications · 80 citations

    3

    h-index

  4. Plant Biotechnology Journal

    3 publications · 163 citations

    3

    h-index

  5. genesis

    3 publications · 73 citations

    3

    h-index

1–5