Concepedia

Lipid Nanoparticle Reactogenicity

Lipid Nanoparticle Reactogenicity is the inherent capacity of lipid nanoparticle-based delivery systems to induce localized or systemic immune activation and inflammatory responses following administration, distinguished from other vaccine adjuvanticity mechanisms by their structural and compositional dependence on synthetic lipid assemblies that interact with innate immune pathways.

8

Publications

310

Citations

129

Authors

32

Institutions

Publications per year

2017–2026

8

Parents

Publications

8

Basophil reactivity to BNT162b2 is mediated by PEGylated lipid nanoparticles in patients with PEG allergy

Alexander Troelnikov, Griffith B. Perkins, Chino Yuson et al. · Journal of Allergy and Clinical Immunology · 2021 · 96 citations

, , +16

Lipid Nanoparticles Elicit Reactogenicity and Sickness Behavior in Mice Via Toll-Like Receptor 4 and Myeloid Differentiation Protein 88 Axis

Tetiana Korzun, Abraham S. Moses, Antony Jozić et al. · ACS Nano · 2024 · 43 citations · Full text

, , +17

Delivery and Expression of mRNA in the Secondary Lymphoid Organs Drive Immune Responses to Lipid Nanoparticle-mRNA Vaccines after Intramuscular Injection

Asuka Takanashi, Colin W. Pouton, Hareth Al-Wassiti · Molecular Pharmaceutics · 2023 · 39 citations · Full text

, , +17

Delivery vehicle and route of administration influences self-amplifying RNA biodistribution, expression kinetics, and reactogenicity

Nuthan Vikas Bathula, Josh J. Friesen, Irafasha C. Casmil et al. · Journal of Controlled Release · 2024 · 35 citations · Full text

, , +17

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

Lulu Huang, Tongyi Zhao, Weijun Zhao et al. · Emerging Microbes & Infections · 2024 · 32 citations · Full text

, , +17

1–5 of 8

Authors

129

  1. KS
    Kongbrailatpam Shitaljit Sharma

    Oregon State University, United States

    1 publications · 43 citations

    1

    h-index

  2. BB
    Bram Bogaert

    Ghent University, Belgium

    1 publications · 31 citations

    1

    h-index

  3. CR
    Carlos R. Celis

    Instituto de Investigación Nutricional, Peru

    1 publications · 20 citations

    1

    h-index

  4. XZ
    Xianhuan Zeng

    China Pharmaceutical University, China

    1 publications · 32 citations

    1

    h-index

  5. YG
    Yingfei Gong

    Shandong University, China

    1 publications · 32 citations

    1

    h-index

1–5 of 129

Institutions

32

  1. Ghent University Hospital

    Ghent, Belgium

    2 h-index

    6 publications

    164 citations

  2. CureVac (Germany)

    Tübingen, Germany

    1 h-index

    11 publications

    220 citations

  3. VIB-UGent Center for Inflammation Research

    Ghent, Belgium

    1 h-index

    4 publications

    124 citations

  4. Oregon Health & Science University

    Portland, United States

    1 h-index

    9 publications

    387 citations

  5. Instituto de Investigación Nutricional

    Lima, Peru

    1 h-index

    5 publications

    100 citations

  6. Monash University

    Melbourne, Australia

    1 h-index

    3 publications

    117 citations

  7. China Pharmaceutical University

    Nanjing, China

    1 h-index

    14 publications

    448 citations

  8. Oregon State University

    Corvallis, United States

    1 h-index

    17 publications

    731 citations

1–8 of 32

Venues

  1. Emerging Microbes & Infections

    1 publications · 32 citations

    1

    h-index

  2. ACS Nano

    1 publications · 43 citations

    1

    h-index

  3. Vaccine X

    1 publications · 20 citations

    1

    h-index

  4. Journal of Allergy and Clinical Immunology

    1 publications · 96 citations

    1

    h-index

  5. Advanced Functional Materials

    1 publications · 31 citations

    1

    h-index

1–5