Concepedia

Ligation Kinetics

Ligation Kinetics is a biochemical framework that characterizes the rate dynamics and mechanistic pathways of phosphodiester bond formation during DNA ligation, distinguishing it from equilibrium-based analyses by focusing on transient reaction phases and enzyme-substrate interactions.

139

Publications

6.8K

Citations

440

Authors

163

Institutions

Publications per year

2017–2026

28

Parents

Publications

139

Mechanistic Investigation of the Staudinger Ligation

Fiona L. Lin, Helen M. Hoyt, Herman van Halbeek et al. · Journal of the American Chemical Society · 2005 · 369 citations

, , +13

Kinetically Controlled Ligation for the Convergent Chemical Synthesis of Proteins

Duhee Bang, Brad L. Pentelute, Stephen B. H. Kent · Angewandte Chemie International Edition · 2006 · 285 citations · Full text

, , +10

Critical Evaluation and Rate Constants of Chemoselective Ligation Reactions for Stoichiometric Conjugations in Water

Fumito Saito, Hidetoshi Noda, Jeffrey W. Bode · ACS Chemical Biology · 2015 · 189 citations

, , +13

Reaction Mechanism and Kinetics of the Traceless Staudinger Ligation

Matthew B. Soellner, Bradley L. Nilsson, Ronald T. Raines · Journal of the American Chemical Society · 2006 · 183 citations

, , +15

General Deoxyribozyme-Catalyzed Synthesis of Native 3‘−5‘ RNA Linkages

Whitney E. Purtha, Rebecca L. Coppins, Mary K. Smalley et al. · Journal of the American Chemical Society · 2005 · 175 citations

, , +10

1–5 of 139

Authors

440

  1. DK
    Diethard K. Böhme

    York University, Canada

    5 publications · 98 citations

    5

    h-index

  2. SS
    Stewart Shuman

    Kettering University, United States

    5 publications · 116 citations

    5

    h-index

  3. VV
    Vitali V. Lavrov

    York University, Canada

    4 publications · 49 citations

    4

    h-index

  4. DM
    Douglas Magde

    University of California San Diego, United States

    4 publications · 109 citations

    4

    h-index

  5. VB
    Voislav Blagojevic

    York University, Canada

    4 publications · 49 citations

    4

    h-index

1–5 of 440

Institutions

163

  1. Kettering University

    Flint, United States

    7 h-index

    13 publications

    448 citations

  2. University of California San Diego

    San Diego, United States

    6 h-index

    20 publications

    499 citations

  3. York University

    Toronto, Canada

    5 h-index

    19 publications

    381 citations

  4. ETH Zurich

    Zurich, Switzerland

    4 h-index

    14 publications

    1.1K citations

  5. University of Illinois Urbana-Champaign

    Urbana, United States

    4 h-index

    8 publications

    875 citations

  6. University of Wisconsin–Madison

    Madison, United States

    3 h-index

    9 publications

    942 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    7 publications

    307 citations

  8. Scripps Research Institute

    San Diego, United States

    3 h-index

    12 publications

    920 citations

1–8 of 163

Venues

  1. Nucleic Acids Research

    22 publications · 1.2K citations

    17

    h-index

  2. Journal of the American Chemical Society

    JACS · 19 publications · 1.7K citations

    17

    h-index

  3. Biochemistry

    11 publications · 445 citations

    11

    h-index

  4. Journal of Biological Chemistry

    JBC · 12 publications · 440 citations

    11

    h-index

  5. RNA

    5 publications · 172 citations

    5

    h-index

1–5