Concepedia

Ligation Efficiency Optimization

Ligation Efficiency Optimization is a methodological framework in molecular biology that systematically enhances the rate and fidelity of DNA strand joining by DNA ligase through the precise modulation of biochemical conditions, enzyme specificity, and substrate design.

26

Publications

1.2K

Citations

122

Authors

43

Institutions

Publications per year

2017–2026

8

Parents

Publications

26

Extending Synthetic Access to Proteins with a Removable Acyl Transfer Auxiliary

John Offer, Christopher N. Boddy, Philip E. Dawson · Journal of the American Chemical Society · 2002 · 276 citations

, , +14

Structural bias in T4 RNA ligase-mediated 3′-adapter ligation

Fanglei Zhuang, Ryan T. Fuchs, Zhiyi Sun et al. · Nucleic Acids Research · 2012 · 202 citations · Full text

, , +13

An Advance in Proline Ligation

Shiying Shang, Zhongping Tan, Suwei Dong et al. · Journal of the American Chemical Society · 2011 · 116 citations

, , +8

Increased Cloning Efficiency by Temperature-Cycle Ligation

Anders H. Lund, Mogens Duch, Finn Skou Pedersen · Nucleic Acids Research · 1996 · 84 citations · Full text

, , +15

Oxo-ester Mediated Native Chemical Ligation: Concept and Applications

Qian Wan, Jin Chen, Yu Yuan et al. · Journal of the American Chemical Society · 2008 · 60 citations

, , +11

1–5 of 26

Authors

122

  1. SJ
    Samuel J. Danishefsky

    Columbia University, United States

    2 publications · 176 citations

    2

    h-index

  2. DJ
    Denise J. Boudreaux

    Baylor College of Medicine, United States

    1 publications · 28 citations

    1

    h-index

  3. RA
    Rachel A. O’Keefe

    University of California, San Francisco, United States

    1 publications · 14 citations

    1

    h-index

  4. BN
    Bart N. Lambrecht

    Ghent University, Belgium

    1 publications · 13 citations

    1

    h-index

  5. KK
    Kent Kirshenbaum

    New York University, United States

    1 publications · 17 citations

    1

    h-index

1–5 of 122

Institutions

43

  1. Kettering University

    Flint, United States

    2 h-index

    8 publications

    704 citations

  2. Columbia University

    New York, United States

    2 h-index

    5 publications

    356 citations

  3. Kyoto University

    Kyoto, Japan

    2 h-index

    6 publications

    262 citations

  4. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    6 publications

    248 citations

  5. Faculty of Public Health

    London, United Kingdom

    1 h-index

    1 publications

    24 citations

  6. University of Northern British Columbia

    Prince George, Canada

    1 h-index

    2 publications

    52 citations

  7. Ghent University

    Ghent, Belgium

    1 h-index

    7 publications

    91 citations

  8. Aarhus University

    Aarhus, Denmark

    1 h-index

    3 publications

    252 citations

1–8 of 43

Venues

  1. Nucleic Acids Research

    5 publications · 367 citations

    5

    h-index

  2. Journal of the American Chemical Society

    JACS · 3 publications · 452 citations

    3

    h-index

  3. Bioconjugate Chemistry

    2 publications · 59 citations

    2

    h-index

  4. ChemBioChem

    2 publications · 47 citations

    2

    h-index

  5. The Journal of Organic Chemistry

    JOC · 1 publications · 15 citations

    1

    h-index

1–5