Concepedia

Ligand-protein Binding Analysis

Ligand-Protein Binding Analysis is a solution-state magnetic resonance methodology that characterizes the molecular interactions between a ligand and its target protein by detecting and quantifying changes in nuclear magnetic resonance parameters arising from binding events.

161

Publications

8.2K

Citations

686

Authors

250

Institutions

Publications per year

2017–2026

36

Parents

Publications

161

Characterization of Ligand Binding by Saturation Transfer Difference NMR Spectroscopy

Moriz Mayer, Bernd Meyer · Angewandte Chemie International Edition · 1999 · 1.6K citations

, , +16

One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds That Bind to Macromolecules

Philip J. Hajduk, Edward T. Olejniczak, Stephen W. Fesik · Journal of the American Chemical Society · 1997 · 368 citations

, , +17

Saturation-Transfer Difference (STD) NMR: A Simple and Fast Method for Ligand Screening and Characterization of Protein Binding

Aldino Viegas, João Manso, Franklin L. Nóbrega et al. · Journal of Chemical Education · 2011 · 314 citations

, , +17

Theory of the time dependent transferred nuclear Overhauser effect: Applications to structural analysis of ligand-protein complexes in solution

G. Marius Clore, Angela M. Gronenborn · Journal of Magnetic Resonance (1969) · 1983 · 285 citations

, , +12

Dual-polarization interferometry: an analytical technique to measure changes in protein structure in real time, to determine the stoichiometry of binding events, and to differentiate between specific and nonspecific interactions

Marcus J. Swann, Louise L Peel, Simon Carrington et al. · Analytical Biochemistry · 2004 · 224 citations

, , +16

1–5 of 161

Authors

686

  1. MM
    Moriz Mayer

    Boehringer Ingelheim (Austria), Austria

    4 publications · 1.7K citations

    4

    h-index

  2. PJ
    Philip J. Hajduk

    Abbott (United States), United States

    3 publications · 563 citations

    3

    h-index

  3. IS
    Ichio Shimada

    The University of Tokyo, Japan

    3 publications · 53 citations

    3

    h-index

  4. SS
    Sakurako Shimotakahara

    Tokyo University of Pharmacy and Life Sciences, Japan

    3 publications · 39 citations

    3

    h-index

  5. MT
    Mitsuru Tashiro

    Meisei University, Japan

    3 publications · 39 citations

    3

    h-index

1–5 of 686

Institutions

250

  1. The University of Tokyo

    Tokyo, Japan

    5 h-index

    14 publications

    178 citations

  2. University of Siena

    Siena, Italy

    4 h-index

    24 publications

    485 citations

  3. National Institute of Advanced Industrial Science and Technology

    Tsukuba, Japan

    4 h-index

    11 publications

    310 citations

  4. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    12 publications

    406 citations

  5. Purdue University West Lafayette

    West Lafayette, United States

    3 h-index

    8 publications

    116 citations

  6. Novartis (Switzerland)

    Basel, Switzerland

    3 h-index

    11 publications

    285 citations

  7. Tokyo University of Pharmacy and Life Sciences

    Hachiōji, Japan

    3 h-index

    4 publications

    52 citations

  8. Granta Design (United Kingdom)

    Cambridge, United Kingdom

    3 h-index

    6 publications

    386 citations

1–8 of 250

Venues

  1. Journal of the American Chemical Society

    JACS · 8 publications · 670 citations

    8

    h-index

  2. Journal of Medicinal Chemistry

    7 publications · 438 citations

    7

    h-index

  3. Angewandte Chemie International Edition

    7 publications · 1.8K citations

    7

    h-index

  4. Journal of Biomolecular NMR

    6 publications · 223 citations

    6

    h-index

  5. Methods in molecular biology

    Book series · 6 publications · 144 citations

    6

    h-index

1–5