Concepedia

Ligand-dependent Conformational Changes

Ligand-Dependent Conformational Changes is a biochemical mechanism in allosteric regulation modeling whereby the binding of a ligand to a macromolecule induces a structural rearrangement that alters the macromolecule's functional activity at a distant site, distinguishing it from intrinsic or ligand-independent conformational fluctuations.

529

Publications

31.8K

Citations

2.4K

Authors

718

Institutions

Publications per year

2017–2026

98

Parents

Publications

529

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

Péter Csermely, Robin Palotai, Ruth Nussinov · Trends in Biochemical Sciences · 2010 · 820 citations · Full text

, , +17

The Key–Lock Theory and the Induced Fit Theory

Daniel E. Koshland · Angewandte Chemie International Edition in English · 1995 · 738 citations

, , +15

Common activation mechanism of class A GPCRs

Qingtong Zhou, Dehua Yang, Meng Wu et al. · eLife · 2019 · 666 citations · Full text

, , +17

Conformational selection or induced fit: A flux description of reaction mechanism

Gordon G. Hammes, Yu‐Chu Chang, Terrence G. Oas · Proceedings of the National Academy of Sciences · 2009 · 580 citations · Full text

, , +17

The Juxtamembrane Region of the Cadherin Cytoplasmic Tail Supports Lateral Clustering, Adhesive Strengthening, and Interaction with p120ctn

Alpha S. Yap, Carien M. Niessen, Barry M. Gumbiner · The Journal of Cell Biology · 1998 · 558 citations · Full text

, , +17

1–5 of 529

Authors

2.4K

  1. HK
    H. K. Schachman

    University of California, Berkeley, United States

    6 publications · 170 citations

    6

    h-index

  2. PT
    Palmer Taylor

    University of California San Diego, United States

    5 publications · 289 citations

    5

    h-index

  3. BK
    Brian K. Kobilka

    Stanford University, United States

    5 publications · 1K citations

    5

    h-index

  4. HR
    H. Ronald Kaback

    University of California, Los Angeles, United States

    5 publications · 224 citations

    5

    h-index

  5. DE
    Daniel E. Koshland

    University of California, Berkeley, United States

    5 publications · 1.4K citations

    5

    h-index

1–5 of 2.4K

Institutions

718

  1. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    77 publications

    3.8K citations

  2. University of California, Berkeley

    Berkeley, United States

    15 h-index

    44 publications

    3.5K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    14 h-index

    32 publications

    3.9K citations

  4. University of California San Diego

    San Diego, United States

    14 h-index

    42 publications

    6K citations

  5. Inserm

    Paris, France

    13 h-index

    47 publications

    2.8K citations

  6. University of California, Los Angeles

    Los Angeles, United States

    11 h-index

    28 publications

    914 citations

  7. National Institutes of Health

    Bethesda, United States

    10 h-index

    49 publications

    1.6K citations

  8. Duke Medical Center

    Durham, United States

    9 h-index

    30 publications

    1.8K citations

1–8 of 718

Venues

  1. Journal of Biological Chemistry

    JBC · 72 publications · 4.1K citations

    36

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 40 publications · 4.3K citations

    33

    h-index

  3. Biochemistry

    66 publications · 3K citations

    32

    h-index

  4. Journal of Molecular Biology

    JMB · 27 publications · 1.3K citations

    21

    h-index

  5. Journal of the American Chemical Society

    JACS · 15 publications · 1.2K citations

    15

    h-index

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