Concepedia

Lefty Signaling

Lefty Signaling is a molecular signaling mechanism in developmental biology that belongs to the class of Nodal-related signaling pathways, distinguished by its specific role in establishing left-right asymmetry through the inhibition of Nodal activity on the right side of the embryonic midline.

52

Publications

5K

Citations

276

Authors

121

Institutions

Publications per year

2017–2026

9

Parents

Publications

52

Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos

Chikara Meno, Yukio Saijoh, Hideta Fujii et al. · Nature · 1996 · 439 citations

, , +16

Differential Diffusivity of Nodal and Lefty Underlies a Reaction-Diffusion Patterning System

Patrick Müller, Katherine W. Rogers, Ben M. Jordan et al. · Science · 2012 · 398 citations

, , +17

Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation

Chikara Meno, Kira Gritsman, Sachiko Oh‐ishi et al. · Molecular Cell · 1999 · 375 citations · Full text

, , +16

Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry

Hidefumi Yoshioka, Chikara Meno, Kazuko Koshiba et al. · Cell · 1998 · 371 citations · Full text

, , +15

Regulation of midline development by antagonism of <i>lefty</i> and <i>nodal</i> signaling

W. Bisgrove Brent, Yost H. Joseph · Development · 1999 · 272 citations

, , +17

1–5 of 52

Authors

276

  1. HH
    Hiroshi Hamada

    The University of Osaka, Japan

    9 publications · 1.9K citations

    9

    h-index

  2. CM
    Chikara Meno

    The University of Osaka, Japan

    6 publications · 1.6K citations

    6

    h-index

  3. AF
    Alexander F. Schier

    Harvard University, United States

    5 publications · 1.2K citations

    5

    h-index

  4. CV
    Christopher V.E. Wright

    Vanderbilt University, United States

    4 publications · 251 citations

    4

    h-index

  5. YS
    Yukio Saijoh

    The University of Osaka, Japan

    4 publications · 923 citations

    4

    h-index

1–5 of 276

Institutions

121

  1. The University of Osaka

    Osaka, Japan

    9 h-index

    41 publications

    9.7K citations

  2. Harvard University

    Cambridge, United States

    5 h-index

    22 publications

    4.7K citations

  3. New York University

    New York, United States

    4 h-index

    13 publications

    2.4K citations

  4. University of Utah

    Salt Lake City, United States

    4 h-index

    10 publications

    1.2K citations

  5. Vanderbilt University

    Nashville, United States

    4 h-index

    8 publications

    493 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    8 publications

    740 citations

  7. Stony Brook University

    Stony Brook, United States

    3 h-index

    6 publications

    191 citations

  8. The Cancer Institute Hospital

    Tokyo, Japan

    2 h-index

    3 publications

    678 citations

1–8 of 121

Venues

  1. Development

    6 publications · 713 citations

    6

    h-index

  2. Developmental Biology

    5 publications · 278 citations

    5

    h-index

  3. Mechanisms of Development

    MOD · 3 publications · 154 citations

    3

    h-index

  4. Journal of Biological Chemistry

    JBC · 3 publications · 294 citations

    3

    h-index

  5. Current Biology

    2 publications · 358 citations

    2

    h-index

1–5