Concepedia

Lariat Formation

Lariat Formation is a biochemical process in which the intron RNA, during splicing, is excised from the pre-messenger RNA and cyclized into a lariat structure through a 2′-5′ phosphodiester bond between the branch point adenosine and the 5′ splice site, marking a key intermediate step in the spliceosome-mediated intron removal pathway.

169

Publications

16.5K

Citations

467

Authors

184

Institutions

Publications per year

2017–2026

8

Parents

Publications

169

SPLICING OF MESSENGER RNA PRECURSORS

Richard A. Padgett, Paula J. Grabowski, Maria M. Konarska et al. · Annual Review of Biochemistry · 1986 · 1.2K citations

, , +15

Splicing of Messenger RNA Precursors

Phillip A. Sharp · Science · 1987 · 922 citations

, , +15

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

Barbara Ruskin, Adrian R. Krainer, Tom Maniatis et al. · Cell · 1984 · 765 citations

, , +14

20 Splicing of Precursors to mRNAs by the Spliceosomes

Christopher B. Burge, Thomas Tuschl, Phillip A. Sharp · 1999 · 539 citations

, , +12

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

Richard A. Padgett, Maria M. Konarska, Paula J. Grabowski et al. · Science · 1984 · 482 citations

, , +15

1–5 of 169

Authors

467

  1. PA
    Phillip A. Sharp

    Massachusetts Institute of Technology, United States

    10 publications · 4.2K citations

    10

    h-index

  2. JA
    John Abelson

    California Institute of Technology, United States

    8 publications · 1.8K citations

    8

    h-index

  3. PJ
    Paula J. Grabowski

    University of Pittsburgh, United States

    6 publications · 2.6K citations

    6

    h-index

  4. RA
    Richard A. Padgett

    Cleveland Clinic, United States

    6 publications · 2.1K citations

    6

    h-index

  5. FM
    François Michel

    Centre de Génétique Moléculaire, France

    5 publications · 162 citations

    5

    h-index

1–5 of 467

Institutions

184

  1. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    38 publications

    1.6K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    9 h-index

    29 publications

    6.5K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    14 publications

    984 citations

  4. Center for Cancer Research

    Bethesda, United States

    8 h-index

    19 publications

    5K citations

  5. Cornell University

    Ithaca, United States

    8 h-index

    13 publications

    1.1K citations

  6. California Institute of Technology

    Pasadena, United States

    8 h-index

    20 publications

    5.3K citations

  7. Uppsala University

    Uppsala, Sweden

    6 h-index

    21 publications

    425 citations

  8. McGill University

    Montreal, Canada

    5 h-index

    13 publications

    325 citations

1–8 of 184

Venues

  1. Nucleic Acids Research

    24 publications · 1.2K citations

    20

    h-index

  2. Molecular and Cellular Biology

    MCB · 15 publications · 1.1K citations

    15

    h-index

  3. RNA

    15 publications · 472 citations

    13

    h-index

  4. Cell

    12 publications · 3.3K citations

    12

    h-index

  5. Science

    9 publications · 2.5K citations

    9

    h-index

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