Concepedia

Kit Inhibitors

KIT Inhibitors is a class of tyrosine kinase inhibitors that specifically target the KIT receptor tyrosine kinase, thereby blocking its aberrant signaling in oncogenic pathways.

195

Publications

19.4K

Citations

1.7K

Authors

523

Institutions

Publications per year

2017–2026

51

Variants

Kit Tyrosine Kinase Inhibitors

Parents

Publications

195

Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal Tumors

George D. Demetri, Margaret von Mehren, Charles D. Blanke et al. · New England Journal of Medicine · 2002 · 4.4K citations · Full text

, , +14

<i>PDGFRA</i> Activating Mutations in Gastrointestinal Stromal Tumors

Michael C. Heinrich, Christopher L. Corless, Anette Duensing et al. · Science · 2003 · 2.3K citations

, , +17

SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer.

Tinya J. Abrams, Leslie B. Lee, Lesley Murray et al. · PubMed · 2003 · 639 citations

, , +17

Structural Basis for the Autoinhibition and STI-571 Inhibition of c-Kit Tyrosine Kinase

Clifford D. Mol, Douglas R. Dougan, T. Schneider et al. · Journal of Biological Chemistry · 2004 · 624 citations · Full text

, , +17

Inhibition of KIT Tyrosine Kinase Activity: A Novel Molecular Approach to the Treatment of KIT-Positive Malignancies

Michael C. Heinrich · Journal of Clinical Oncology · 2002 · 580 citations

, , +17

1–5 of 195

Authors

1.7K

  1. MC
    Michael C. Heinrich

    Oregon Health & Science University, United States

    15 publications · 8.3K citations

    14

    h-index

  2. JA
    Jonathan A. Fletcher

    Brigham and Women's Hospital, United States

    13 publications · 7.6K citations

    13

    h-index

  3. GD
    George D. Demetri

    Dana-Farber Cancer Institute, United States

    9 publications · 7.6K citations

    9

    h-index

  4. PS
    Patrick Schöffski

    KU Leuven, Belgium

    8 publications · 495 citations

    8

    h-index

  5. MD
    Maria Dêbiec‐Rychter

    KU Leuven, Belgium

    7 publications · 490 citations

    7

    h-index

1–5 of 1.7K

Institutions

523

  1. Dana-Farber Cancer Institute

    Boston, United States

    20 h-index

    104 publications

    46.4K citations

  2. Harvard University

    Cambridge, United States

    15 h-index

    67 publications

    11.3K citations

  3. Brigham and Women's Hospital

    Boston, United States

    14 h-index

    45 publications

    16.7K citations

  4. Memorial Sloan Kettering Cancer Center

    New York, United States

    14 h-index

    127 publications

    7.2K citations

  5. Oregon Health & Science University

    Portland, United States

    11 h-index

    42 publications

    31.8K citations

  6. The University of Texas MD Anderson Cancer Center

    Houston, United States

    11 h-index

    43 publications

    2.4K citations

  7. KU Leuven

    Leuven, Belgium

    10 h-index

    48 publications

    2.5K citations

  8. Portland VA Medical Center

    Portland, United States

    8 h-index

    15 publications

    21.5K citations

1–8 of 523

Venues

  1. Journal of Clinical Oncology

    19 publications · 923 citations

    13

    h-index

  2. Clinical Cancer Research

    12 publications · 967 citations

    12

    h-index

  3. Journal of Medicinal Chemistry

    11 publications · 447 citations

    11

    h-index

  4. PubMed

    Repository · 11 publications · 1.5K citations

    11

    h-index

  5. Cancer Research

    11 publications · 832 citations

    11

    h-index

1–5