Concepedia

Iterative Profile Refinement

Iterative Profile Refinement is a computational method in the context of Profile Hidden Markov Models that progressively enhances the alignment and parameter estimation of the model by successively retraining on updated sequence alignments to improve sensitivity and specificity in remote homology detection.

3

Publications

551

Citations

6

Authors

3

Institutions

Publications per year

2017–2026

0

Parents

Publications

3

Rapid automatic detection and alignment of repeats in protein sequences

Andreas Heger, Liisa Holm · Proteins Structure Function and Bioinformatics · 2000 · 340 citations

, , +15

An evolutionary classification of the metallo-beta-lactamase fold proteins.

L. Aravind · PubMed · 1999 · 180 citations

, , +16

An Evolutionary Classification of the Metallo-ß-Lactamase Fold Proteins

L. Aravind · In Silico Biology · 1999 · 76 citations

, , +15

Simple is beautiful: a straightforward approach to improve the delineation of true and false positives in PSI-BLAST searches

Marianne M. Lee, Michael K. Chan, Ralf Bundschuh · Bioinformatics · 2008 · 31 citations · Full text

, , +14

1–4 of 3

Authors

6

  1. MK
    Michael K. Chan

    The Ohio State University, United States

    1 publications · 31 citations

    1

    h-index

  2. MM
    Marianne M. Lee

    Chinese University of Hong Kong, Hong Kong SAR China

    1 publications · 31 citations

    1

    h-index

  3. LH
    Liisa Holm

    University of Helsinki, Finland

    1 publications · 340 citations

    1

    h-index

  4. AH
    Andreas Heger

    University of Oxford, United Kingdom

    1 publications · 340 citations

    1

    h-index

  5. LA
    L. Aravind

    National Center for Biotechnology Information, United States

    1 publications · 180 citations

    1

    h-index

1–5 of 6

Institutions

3

  1. The Ohio State University

    Columbus, United States

    1 h-index

    3 publications

    93 citations

  2. European Bioinformatics Institute

    Cambridge, United Kingdom

    1 h-index

    2 publications

    680 citations

  3. National Center for Biotechnology Information

    Bethesda, United States

    1 h-index

    1 publications

    180 citations

  4. National Institutes of Health

    Bethesda, United States

    1 publications

    76 citations

1–4 of 3

Venues

  1. Bioinformatics

    1 publications · 31 citations

    1

    h-index

  2. Proteins Structure Function and Bioinformatics

    1 publications · 340 citations

    1

    h-index

  3. PubMed

    Repository · 1 publications · 180 citations

    1

    h-index

  4. In Silico Biology

    ISB · 1 publications · 76 citations

1–4