Concepedia

Irreversible Activation

Irreversible Activation is a type of enzyme activation mechanism in which the activation process permanently modifies the enzyme's structure or covalent state, thereby preventing reversion to the inactive form under physiological conditions.

112

Publications

6.6K

Citations

409

Authors

154

Institutions

Publications per year

2017–2026

18

Parents

Publications

112

Activation of the Cardiac Calcium Release Channel (Ryanodine Receptor) by Poly-S-Nitrosylation

Le Xu, Jerry P. Eu, Gerhard Meissner et al. · Science · 1998 · 976 citations

, , +17

Enzyme-Activated Irreversible Inhibitors

Keith F. Tipton · Biochemical Society Transactions · 1979 · 420 citations

, , +9

Binding of 14-3-3 Protein to the Plasma Membrane H+-ATPase AHA2 Involves the Three C-terminal Residues Tyr946-Thr-Val and Requires Phosphorylation of Thr947

Anja T. Fuglsang, Sabina Visconti, Katrine Drumm et al. · Journal of Biological Chemistry · 1999 · 339 citations · Full text

, , +14

Activation Mechanism of LiNi<sub>0.80</sub>Co<sub>0.15</sub>Al<sub>0.05</sub>O<sub>2</sub>: Surface and Bulk Operando Electrochemical, Differential Electrochemical Mass Spectrometry, and X-ray Diffraction Analyses

Rosa Robert, Christa Bünzli, Erik J. Berg et al. · Chemistry of Materials · 2014 · 227 citations

, , +17

Kinetic and spectroscopic evidence for an irreversible step between deprotonation and reprotonation of the Schiff base in the bacteriorhodopsin photocycle

György Váró, Janos K. Lanyi · Biochemistry · 1991 · 221 citations

, , +14

1–5 of 112

Authors

409

  1. BL
    B Leckie

    Western Infirmary, United Kingdom

    2 publications · 83 citations

    2

    h-index

  2. VF
    Vincent Fourmond

    Centre National de la Recherche Scientifique, France

    2 publications · 74 citations

    2

    h-index

  3. SA
    Stuart A. Macgregor

    Heriot-Watt University, United Kingdom

    2 publications · 146 citations

    2

    h-index

  4. AS
    Amit S. Kalgutkar

    Pfizer (United States), United States

    2 publications · 29 citations

    2

    h-index

  5. MS
    Michael Schmittel

    University of Siegen, Germany

    2 publications · 148 citations

    2

    h-index

1–5 of 409

Institutions

154

  1. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    19 publications

    775 citations

  2. National Institutes of Health

    Bethesda, United States

    4 h-index

    9 publications

    484 citations

  3. University of California San Diego

    San Diego, United States

    3 h-index

    11 publications

    472 citations

  4. University of Washington

    Seattle, United States

    3 h-index

    8 publications

    614 citations

  5. Northwestern University

    Evanston, United States

    3 h-index

    8 publications

    155 citations

  6. Aix-Marseille Université

    Marseille, France

    2 h-index

    12 publications

    540 citations

  7. Columbia University

    New York, United States

    2 h-index

    5 publications

    234 citations

  8. Pfizer (United States)

    New York, United States

    2 h-index

    19 publications

    298 citations

1–8 of 154

Venues

  1. Journal of Biological Chemistry

    JBC · 14 publications · 1K citations

    14

    h-index

  2. PubMed

    Repository · 7 publications · 182 citations

    7

    h-index

  3. Biochemistry

    6 publications · 365 citations

    6

    h-index

  4. Journal of Medicinal Chemistry

    5 publications · 194 citations

    5

    h-index

  5. Journal of the American Chemical Society

    JACS · 4 publications · 365 citations

    4

    h-index

1–5