Concepedia

Interface Hotspot Identification

Interface Hotspot Identification is a computational or experimental method that identifies specific residues within a protein-protein interaction interface that disproportionately contribute to binding affinity and stability, thereby distinguishing them from surrounding residues with lesser functional impact.

51

Publications

3.9K

Citations

183

Authors

87

Institutions

Publications per year

2017–2026

15

Parents

Publications

51

Hot Regions in Protein–Protein Interactions: The Organization and Contribution of Structurally Conserved Hot Spot Residues

Özlem Keskin, Buyong Ma, Ruth Nussinov · Journal of Molecular Biology · 2004 · 522 citations

, , +15

Identification of computational hot spots in protein interfaces: combining solvent accessibility and inter-residue potentials improves the accuracy

Nurcan Tunçbağ, Attila Gürsoy, Özlem Keskin · Bioinformatics · 2009 · 265 citations · Full text

, , +13

An automated decision‐tree approach to predicting protein interaction hot spots

Steven J. Darnell, David Page, Julie C. Mitchell · Proteins Structure Function and Bioinformatics · 2007 · 219 citations

, , +17

APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility

Junfeng Xia, Xing-Ming Zhao, Jiangning Song et al. · BMC Bioinformatics · 2010 · 212 citations · Full text

, , +14

Small‐world network approach to identify key residues in protein–protein interaction

Antonio del Sol, Paul O’Meara · Proteins Structure Function and Bioinformatics · 2004 · 172 citations · Full text

, , +14

1–5 of 51

Authors

183

  1. LD
    Lei Deng

    Central South University, China

    4 publications · 266 citations

    4

    h-index

  2. JX
    Junfeng Xia

    Anhui University, China

    4 publications · 315 citations

    4

    h-index

  3. ÖK
    Özlem Keskin

    Koç University, Türkiye

    4 publications · 967 citations

    4

    h-index

  4. IS
    Irina S. Moreira

    Universidade do Porto, Portugal

    3 publications · 198 citations

    3

    h-index

  5. AG
    Attila Gürsoy

    Koç University, Türkiye

    3 publications · 445 citations

    3

    h-index

1–5 of 183

Institutions

87

  1. Anhui University

    Hefei, China

    5 h-index

    21 publications

    821 citations

  2. Koç University

    Istanbul, Türkiye

    4 h-index

    12 publications

    2K citations

  3. Fudan University

    Shanghai, China

    4 h-index

    4 publications

    188 citations

  4. Nanyang Technological University

    Singapore, Singapore

    3 h-index

    10 publications

    408 citations

  5. Central South University

    Changsha, China

    3 h-index

    7 publications

    648 citations

  6. Tongji University

    Shanghai, China

    3 h-index

    10 publications

    314 citations

  7. Universidade do Porto

    Porto, Portugal

    3 h-index

    9 publications

    495 citations

  8. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    9 publications

    494 citations

1–8 of 87

Venues

  1. Proteins Structure Function and Bioinformatics

    6 publications · 541 citations

    6

    h-index

  2. BMC Bioinformatics

    6 publications · 395 citations

    6

    h-index

  3. Journal of Chemical Information and Modeling

    JCIM · 5 publications · 142 citations

    5

    h-index

  4. Nucleic Acids Research

    4 publications · 463 citations

    4

    h-index

  5. Bioinformatics

    4 publications · 595 citations

    4

    h-index

1–5