Concepedia

Interaction Hotspot Identification

Interaction Hotspot Identification is a computational or experimental method that pinpoints specific residues or regions within a protein interface that disproportionately contribute to the binding affinity and specificity of protein-protein interactions.

32

Publications

2.1K

Citations

158

Authors

77

Institutions

Publications per year

2017–2026

11

Parents

Publications

32

Hot Regions in Protein–Protein Interactions: The Organization and Contribution of Structurally Conserved Hot Spot Residues

Özlem Keskin, Buyong Ma, Ruth Nussinov · Journal of Molecular Biology · 2004 · 522 citations

, , +15

A feature-based approach to modeling protein–protein interaction hot spots

Kyu-Il Cho, Dongsup Kim, Doheon Lee · Nucleic Acids Research · 2009 · 171 citations · Full text

, , +13

The binding interfacedatabase (BID): a compilationof amino acid hot spots in protein interfaces

Tiffany B. Fischer, K. V. Arunachalam, David Bailey et al. · Bioinformatics · 2003 · 167 citations · Full text

, , +17

KFC Server: interactive forecasting of protein interaction hot spots

Steven J. Darnell, Lisa Legault, Julie C. Mitchell · Nucleic Acids Research · 2008 · 158 citations · Full text

, , +16

Hot spot-based design of small-molecule inhibitors for protein–protein interactions

Wenxing Guo, John A. Wisniewski, Haitao Ji · Bioorganic & Medicinal Chemistry Letters · 2014 · 142 citations · Full text

, , +17

1–5 of 32

Authors

158

  1. CL
    Carmay Lim

    National Tsing Hua University, Taiwan

    2 publications · 59 citations

    2

    h-index

  2. ZZ
    Zhiwang Zhang

    Ludong University, China

    2 publications · 31 citations

    2

    h-index

  3. YS
    Yong Shi

    Chinese Academy of Sciences, China

    2 publications · 31 citations

    2

    h-index

  4. SZ
    Shuigeng Zhou

    Fudan University, China

    2 publications · 122 citations

    2

    h-index

  5. JS
    Joan Segura

    San Diego Supercomputer Center, United States

    2 publications · 41 citations

    2

    h-index

1–5 of 158

Institutions

77

  1. Tongji University

    Shanghai, China

    3 h-index

    7 publications

    356 citations

  2. Koç University

    Istanbul, Türkiye

    2 h-index

    4 publications

    654 citations

  3. Ludong University

    Yantai, China

    2 h-index

    3 publications

    46 citations

  4. University of Nebraska at Omaha

    Omaha, United States

    2 h-index

    2 publications

    31 citations

  5. Central South University

    Changsha, China

    2 h-index

    4 publications

    270 citations

  6. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    5 publications

    79 citations

  7. Institute of Biomedical Sciences, Academia Sinica

    Taipei, Taiwan

    2 h-index

    8 publications

    254 citations

  8. Wuhan University of Science and Technology

    Wuhan, China

    2 h-index

    5 publications

    92 citations

1–8 of 77

Venues

  1. Nucleic Acids Research

    4 publications · 423 citations

    4

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 3 publications · 88 citations

    3

    h-index

  3. Journal of Molecular Biology

    JMB · 2 publications · 616 citations

    2

    h-index

  4. BMC Bioinformatics

    2 publications · 37 citations

    2

    h-index

  5. Chemistry & Biology

    1 publications · 79 citations

    1

    h-index

1–5