Concepedia

Integrin-mediated Resorption

Integrin-Mediated Resorption is a biological process in bone remodeling wherein osteoclasts resorb bone tissue through the activation of intracellular signaling pathways initiated by the binding of integrin receptors to extracellular matrix proteins, primarily involving αvβ3 integrin engagement.

58

Publications

4.8K

Citations

296

Authors

107

Institutions

Publications per year

2017–2026

6

Parents

Publications

58

Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts

Kevin P. McHugh, Kairbaan Hodivala‐Dilke, Minghao Zheng et al. · Journal of Clinical Investigation · 2000 · 724 citations · Full text

, , +17

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

F. Patrick Ross, Jean Chappel, Justo Álvarez et al. · Journal of Biological Chemistry · 1993 · 533 citations · Full text

, , +17

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.

V. Wayne Engleman, G. Allen Nickols, F. Patrick Ross et al. · Journal of Clinical Investigation · 1997 · 287 citations · Full text

, , +17

Tumor αvβ3 Integrin Is a Therapeutic Target for Breast Cancer Bone Metastases

Yingshe Zhao, Richard Bachelier, Isabelle Treilleux et al. · Cancer Research · 2007 · 208 citations · Full text

, , +17

Role of αvβ3 integrin in osteoclast migration and formation of the sealing zone

Ichiro Nakamura, Mary F. Pilkington, Päivi T. Lakkakorpi et al. · Journal of Cell Science · 1999 · 197 citations

, , +14

1–5 of 58

Authors

296

  1. SL
    Steven L. Teitelbaum

    Washington University in St. Louis, United States

    14 publications · 2.2K citations

    13

    h-index

  2. FP
    F. Patrick Ross

    Washington University in St. Louis, United States

    12 publications · 2.1K citations

    12

    h-index

  3. GA
    Gideon A. Rodan

    United States Military Academy, United States

    5 publications · 516 citations

    5

    h-index

  4. RF
    Roberta Faccio

    Washington University in St. Louis, United States

    4 publications · 307 citations

    4

    h-index

  5. MA
    Michael A. Horton

    University College London, United Kingdom

    4 publications · 153 citations

    4

    h-index

1–5 of 296

Institutions

107

  1. Washington University in St. Louis

    St Louis, United States

    12 h-index

    68 publications

    9.8K citations

  2. Jewish Hospital

    Louisville, United States

    7 h-index

    30 publications

    5.8K citations

  3. United States Military Academy

    West Point, United States

    7 h-index

    41 publications

    3.9K citations

  4. University College London

    London, United Kingdom

    5 h-index

    13 publications

    912 citations

  5. Yale University

    New Haven, United States

    4 h-index

    9 publications

    509 citations

  6. Washington University Medical Center

    St Louis, United States

    4 h-index

    16 publications

    875 citations

  7. University of Bari Aldo Moro

    Bari, Italy

    3 h-index

    10 publications

    641 citations

  8. Mallinckrodt (United States)

    Hazelwood, United States

    2 h-index

    7 publications

    308 citations

1–8 of 107

Venues

  1. Endocrinology

    9 publications · 520 citations

    9

    h-index

  2. Journal of Bone and Mineral Research

    JBMR · 8 publications · 400 citations

    8

    h-index

  3. Journal of Biological Chemistry

    JBC · 4 publications · 726 citations

    4

    h-index

  4. Journal of Cellular Biochemistry

    3 publications · 87 citations

    3

    h-index

  5. Journal of Clinical Investigation

    JCI · 3 publications · 1.1K citations

    3

    h-index

1–5