Concepedia

Hydrophobicity Optimization

Hydrophobicity Optimization is a computational or experimental methodology旨在 systematically adjusting the nonpolar character of a molecule to enhance its lipophilic properties while balancing solubility, permeability, and metabolic stability in drug design.

157

Publications

7.1K

Citations

876

Authors

299

Institutions

Publications per year

2017–2026

74

Parents

Publications

157

Hydrophobicity and Central Nervous System Agents: On the Principle of Minimal Hydrophobicity in Drug Design

Corwin Hansch, J.P. Björkroth, Albert J. Leo · Journal of Pharmaceutical Sciences · 1987 · 435 citations

, , +14

Development of hydrophobicity parameters to analyze proteins which bear post- or cotranslational modifications

Shaun D. Black, Diane R. Mould · Analytical Biochemistry · 1991 · 380 citations

, , +13

A hydrophobic hole transporting oligothiophene for planar perovskite solar cells with improved stability

Lingling Zheng, Yao‐Hsien Chung, Yingzhuang Ma et al. · Chemical Communications · 2014 · 273 citations

, , +17

Sequence-Specific Retention Calculator. Algorithm for Peptide Retention Prediction in Ion-Pair RP-HPLC:  Application to 300- and 100-Å Pore Size C18 Sorbents

Oleg V. Krokhin · Analytical Chemistry · 2006 · 230 citations

, , +14

Signature of Pareto optimization in the Escherichia coli proteome

Loren Koçillari, Piero Fariselli, Antonio Trovato et al. · Scientific Reports · 2018 · 177 citations · Full text

, , +17

1–5 of 157

Authors

876

  1. JH
    Jayanta Haldar

    Jawaharlal Nehru Centre for Advanced Scientific Research, India

    3 publications · 177 citations

    3

    h-index

  2. YK
    Yuki Kohno

    Tokyo University of Agriculture and Technology, Japan

    2 publications · 34 citations

    2

    h-index

  3. KM
    K. Marinova

    Sofia University "St. Kliment Ohridski", Bulgaria

    2 publications · 67 citations

    2

    h-index

  4. SB
    Swagatam Barman

    Jawaharlal Nehru Centre for Advanced Scientific Research, India

    2 publications · 55 citations

    2

    h-index

  5. ND
    Nicholas D. Posey

    University of Massachusetts Amherst, United States

    2 publications · 51 citations

    2

    h-index

1–5 of 876

Institutions

299

  1. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    25 publications

    876 citations

  2. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    21 publications

    745 citations

  3. University of Chinese Academy of Sciences

    Beijing, China

    4 h-index

    6 publications

    166 citations

  4. Uppsala University

    Uppsala, Sweden

    3 h-index

    9 publications

    289 citations

  5. Iowa State University

    Ames, United States

    3 h-index

    15 publications

    617 citations

  6. China University of Petroleum, East China

    Qingdao, China

    3 h-index

    16 publications

    368 citations

  7. China National Petroleum Corporation (China)

    Beijing, China

    3 h-index

    6 publications

    179 citations

  8. Jawaharlal Nehru Centre for Advanced Scientific Research

    Bengaluru, India

    3 h-index

    16 publications

    904 citations

1–8 of 299

Venues

  1. Carbohydrate Polymers

    4 publications · 253 citations

    4

    h-index

  2. Journal of Pharmaceutical Sciences

    4 publications · 490 citations

    4

    h-index

  3. Biomacromolecules

    4 publications · 186 citations

    4

    h-index

  4. Bioorganic & Medicinal Chemistry

    4 publications · 109 citations

    4

    h-index

  5. Analytical Chemistry

    3 publications · 319 citations

    3

    h-index

1–5