Concepedia

Hydrogen Bond Network Optimization

Hydrogen Bond Network Optimization is an active site engineering strategy that systematically refines the spatial arrangement and energetics of hydrogen-bonding interactions within an enzyme's catalytic pocket to enhance structural stability, substrate specificity, or catalytic efficiency.

56

Publications

2.8K

Citations

224

Authors

90

Institutions

Publications per year

2017–2026

25

Parents

Publications

56

Positioning hydrogen atoms by optimizing hydrogen-bond networks in protein structures

Rob Hooft, Chris Sander, Gerrit Vriend · Proteins Structure Function and Bioinformatics · 1996 · 302 citations

, , +17

Assignment of Protonation States in Proteins and Ligands: Combining pKa Prediction with Hydrogen Bonding Network Optimization

Elmar Krieger, Roland L. Dunbrack, Rob Hooft et al. · Methods in molecular biology · 2011 · 281 citations

, , +14

Optimizing the hydrogen‐bond network in Poisson–Boltzmann equation‐based p<i>K</i><sub>a</sub> calculations

Jens Erik Nielsen, Gerrit Vriend · Proteins Structure Function and Bioinformatics · 2001 · 219 citations

, , +17

Computational Design of a New Hydrogen Bond Network and at Least a 300-fold Specificity Switch at a Protein−Protein Interface

Łukasz A. Joachimiak, Tanja Kortemme, Barry Stoddard et al. · Journal of Molecular Biology · 2006 · 141 citations

, , +17

Prediction of protein conformation on the basis of a search for compact structures: Test on avian pancreatic polypeptide

Adam Liwo, Ryszard J. Wawak, Harold A. Scheraga et al. · Protein Science · 1993 · 139 citations · Full text

, , +17

1–5 of 56

Authors

224

  1. YY
    Yongrong Yang

    Zhejiang University, China

    4 publications · 187 citations

    4

    h-index

  2. JW
    Jingdai Wang

    Zhejiang University, China

    4 publications · 187 citations

    4

    h-index

  3. ZL
    Zuwei Liao

    Zhejiang University, China

    4 publications · 187 citations

    4

    h-index

  4. GV
    Gerrit Vriend

    Radboud University Nijmegen, Netherlands

    3 publications · 536 citations

    3

    h-index

  5. BJ
    Binbo Jiang

    Zhejiang University, China

    3 publications · 116 citations

    3

    h-index

1–5 of 224

Institutions

90

  1. Zhejiang University

    Hangzhou, China

    6 h-index

    27 publications

    954 citations

  2. State Key Laboratory of Chemical Engineering

    Hangzhou, China

    4 h-index

    16 publications

    672 citations

  3. China University of Petroleum, Beijing

    Beijing, China

    2 h-index

    5 publications

    183 citations

  4. Virginia Commonwealth University

    Richmond, United States

    2 h-index

    5 publications

    116 citations

  5. Nanjing University

    Nanjing, China

    1 h-index

    4 publications

    56 citations

  6. Gene Therapy Laboratory

    Nantes, France

    1 h-index

    1 publications

    11 citations

  7. Silesian University of Technology

    Gliwice, Poland

    1 h-index

    1 publications

    113 citations

  8. Dalhousie University

    Halifax, Canada

    1 h-index

    4 publications

    224 citations

1–8 of 90

Venues

  1. International Journal of Hydrogen Energy

    6 publications · 208 citations

    6

    h-index

  2. Proteins Structure Function and Bioinformatics

    5 publications · 587 citations

    5

    h-index

  3. Energy

    3 publications · 147 citations

    3

    h-index

  4. Chemical Engineering Journal

    2 publications · 35 citations

    3

    h-index

  5. The Journal of Chemical Physics

    2 publications · 110 citations

    2

    h-index

1–5