Concepedia

Host Cell Line Engineering

Host Cell Line Engineering is the systematic modification of a host cell line's genetic and physiological properties to enhance its capacity for the efficient and scalable production of recombinant proteins, distinguishing it from other protein expression strategies by its focus on host-level optimization rather than vector or process-level improvements.

94

Publications

4.8K

Citations

562

Authors

159

Institutions

Publications per year

2017–2026

22

Parents

Publications

94

Establishment of <i>FUT8</i> knockout Chinese hamster ovary cells: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody‐dependent cellular cytotoxicity

Naoko Yamane‐Ohnuki, Satoko Kinoshita, Miho Inoue‐Urakubo et al. · Biotechnology and Bioengineering · 2004 · 574 citations

, , +16

Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.

M Haraguchi, S. Yamashiro, Akira Yamamoto et al. · Proceedings of the National Academy of Sciences · 1994 · 212 citations

, , +15

Genetic characterization of CHO production host DG44 and derivative recombinant cell lines

Madiha Derouazi, Danielle Martinet, Nathalie Besuchet Schmutz et al. · Biochemical and Biophysical Research Communications · 2005 · 152 citations · Full text

, , +14

Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells

Lianchun Fan, Ibrahim Kadura, Lara E. Krebs et al. · Biotechnology and Bioengineering · 2011 · 147 citations

, , +17

A high‐yielding CHO transient system: Coexpression of genes encoding EBNA‐1 and GS enhances transient protein expression

Olalekan Daramola, Jessica Stevenson, Greg Dean et al. · Biotechnology Progress · 2013 · 138 citations

, , +17

1–5 of 94

Authors

562

  1. HD
    Haimanti Dorai

    Johns Hopkins University, United States

    3 publications · 157 citations

    3

    h-index

  2. DH
    Diane Hatton

    AstraZeneca (United Kingdom), United Kingdom

    3 publications · 183 citations

    3

    h-index

  3. NB
    Nicole Borth

    BOKU University, Austria

    3 publications · 136 citations

    3

    h-index

  4. MJ
    Michael J. Betenbaugh

    Johns Hopkins University, United States

    3 publications · 164 citations

    3

    h-index

  5. OD
    Olalekan Daramola

    University of Sheffield, United Kingdom

    3 publications · 190 citations

    3

    h-index

1–5 of 562

Institutions

159

  1. Biotechnology Institute

    Washington D.C., United States

    4 h-index

    12 publications

    448 citations

  2. Johns Hopkins University

    Baltimore, United States

    4 h-index

    7 publications

    270 citations

  3. BOKU University

    Vienna, Austria

    4 h-index

    17 publications

    1.1K citations

  4. Bioprocessing Technology Institute

    Singapore, Singapore

    4 h-index

    38 publications

    2.9K citations

  5. Agency for Science, Technology and Research

    Singapore, Singapore

    4 h-index

    48 publications

    3.7K citations

  6. Helmholtz Centre for Infection Research

    Braunschweig, Germany

    3 h-index

    10 publications

    570 citations

  7. Lonza (United Kingdom)

    Slough, United Kingdom

    3 h-index

    6 publications

    236 citations

  8. Pfizer (United States)

    New York, United States

    3 h-index

    11 publications

    758 citations

1–8 of 159

Venues

  1. Biotechnology and Bioengineering

    16 publications · 1.3K citations

    15

    h-index

  2. Biotechnology Progress

    12 publications · 587 citations

    12

    h-index

  3. Biotechnology Journal

    4 publications · 203 citations

    4

    h-index

  4. Journal of Biotechnology

    4 publications · 208 citations

    4

    h-index

  5. Methods in molecular biology

    Book series · 3 publications · 82 citations

    3

    h-index

1–5