Concepedia

Holdase Function

Holdase Function is a chaperone-mediated biochemical mechanism that belongs to the class of protein-folding regulatory processes, distinguished by its capacity to prevent the aggregation of misfolded or partially folded polypeptides through stable, non-covalent binding without facilitating their folding.

24

Publications

931

Citations

151

Authors

60

Institutions

Publications per year

2017–2026

16

Parents

Publications

24

Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer-membrane proteins

Johannes Thoma, Björn M. Burmann, Sebastian Hiller et al. · Nature Structural & Molecular Biology · 2015 · 118 citations

, , +14

Heat-shock dependent oligomeric status alters the function of a plant-specific thioredoxin-like protein, AtTDX

Jung Ro Lee, Seung Sik Lee, Ho Hee Jang et al. · Proceedings of the National Academy of Sciences · 2009 · 113 citations · Full text

, , +17

Oligomerization of a molecular chaperone modulates its activity

Tomohide Saio, Soichiro Kawagoe, Koichiro Ishimori et al. · eLife · 2018 · 74 citations · Full text

, , +17

A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis

Ponni Rajagopal, Eric Tse, Andrew J. Borst et al. · eLife · 2015 · 73 citations · Full text

, , +17

Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in <i>Drosophila</i>

Pedro Fernández-Fúnez, Jonatan Sanchez-Garcia, Lorena de Mena et al. · Proceedings of the National Academy of Sciences · 2016 · 72 citations · Full text

, , +17

1–5 of 24

Authors

151

  1. RE
    Rachel E. Klevit

    University of Washington, United States

    2 publications · 102 citations

    2

    h-index

  2. UJ
    Ursula Jakob

    University of Michigan, United States

    2 publications · 46 citations

    2

    h-index

  3. DV
    Didier Vertommen

    de Duve Institute, Belgium

    2 publications · 51 citations

    2

    h-index

  4. CM
    Claudia M. Cremers

    University of Michigan, United States

    2 publications · 46 citations

    2

    h-index

  5. SJ
    Sander J. Tans

    Institute for Atomic and Molecular Physics, Netherlands

    2 publications · 38 citations

    2

    h-index

1–5 of 151

Institutions

60

  1. University of Michigan

    Ann Arbor, United States

    3 h-index

    7 publications

    257 citations

  2. University of Washington

    Seattle, United States

    3 h-index

    10 publications

    525 citations

  3. Ruhr University Bochum

    Bochum, Germany

    2 h-index

    11 publications

    375 citations

  4. de Duve Institute

    Brussels, Belgium

    2 h-index

    7 publications

    176 citations

  5. Institute for Atomic and Molecular Physics

    Amsterdam, The Netherlands

    2 h-index

    5 publications

    95 citations

  6. VIB-VUB Center for Structural Biology

    Brussels, Belgium

    1 h-index

    6 publications

    156 citations

  7. Johns Hopkins Medicine

    Baltimore, United States

    1 h-index

    4 publications

    52 citations

  8. Institute of Sciences of Food Production

    Bari, Italy

    1 h-index

    1 publications

    20 citations

1–8 of 60

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 244 citations

    4

    h-index

  2. Biochemistry

    2 publications · 41 citations

    2

    h-index

  3. mBio

    2 publications · 56 citations

    2

    h-index

  4. eLife

    2 publications · 147 citations

    2

    h-index

  5. Biophysical Journal

    2 publications · 36 citations

    2

    h-index

1–5