Concepedia

High-throughput Screening Cycles

High-Throughput Screening Cycles is a methodological framework in directed evolution that enables the parallel evaluation of vast libraries of ribosome-displayed proteins through iterative rounds of selection, amplification, and enrichment to identify high-affinity binders with enhanced efficiency and throughput.

67

Publications

2.8K

Citations

358

Authors

130

Institutions

Publications per year

2017–2026

23

Parents

Publications

67

High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase

Jan Blanchard, Nadine H. Elowe, Carly Huitema et al. · Chemistry & Biology · 2004 · 215 citations · Full text

, , +13

Genetic Screens and Selections for Small Molecules Based on a Synthetic Riboswitch That Activates Protein Translation

Shawn K. Desai, Justin P. Gallivan · Journal of the American Chemical Society · 2004 · 211 citations

, , +15

A microscale protein NMR sample screening pipeline

Paolo Rossi, G.V.T. Swapna, Yuanpeng J. Huang et al. · Journal of Biomolecular NMR · 2009 · 139 citations · Full text

, , +16

Robust, Cost-Effective Profiling of RNA Binding Protein Targets with Single-end Enhanced Crosslinking and Immunoprecipitation (seCLIP)

Eric L. Van Nostrand, Thai B. Nguyen, Chelsea Gelboin-Burkhart et al. · Methods in molecular biology · 2017 · 123 citations · Full text

, , +12

High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble

Laura R. Ganser, Jang Hyun Lee, Atul Rangadurai et al. · Nature Structural & Molecular Biology · 2018 · 113 citations · Full text

, , +8

1–5 of 67

Authors

358

  1. CA
    Craig A. Simmons

    University of Toronto, Canada

    1 publications · 20 citations

    1

    h-index

  2. VS
    Vladimir Shchurik

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    1 publications · 20 citations

    1

    h-index

  3. HZ
    Huifen Zhao

    Université Laval, Canada

    1 publications · 36 citations

    1

    h-index

  4. PL
    Pei-Yu Liao

    University of Delaware, United States

    1 publications · 19 citations

    1

    h-index

  5. SN
    Shunji Nagahara

    Sumitomo Dainippon Pharma (Japan), Japan

    1 publications · 81 citations

    1

    h-index

1–5 of 358

Institutions

130

  1. University of California San Diego

    San Diego, United States

    3 h-index

    10 publications

    1.1K citations

  2. Scripps Research Institute

    San Diego, United States

    2 h-index

    11 publications

    536 citations

  3. Rutgers, The State University of New Jersey

    New Brunswick, United States

    2 h-index

    13 publications

    1.6K citations

  4. Emory University

    Atlanta, United States

    2 h-index

    3 publications

    439 citations

  5. McGill University

    Montreal, Canada

    2 h-index

    4 publications

    93 citations

  6. University of Science and Technology of China

    Hefei, China

    2 h-index

    3 publications

    197 citations

  7. Structural Genomics Consortium

    Toronto, Canada

    2 h-index

    4 publications

    102 citations

  8. Eugene Applebaum College of Pharmacy and Health Sciences

    Detroit, United States

    1 h-index

    3 publications

    66 citations

1–8 of 130

Venues

  1. Methods in molecular biology

    Book series · 5 publications · 182 citations

    5

    h-index

  2. Nucleic Acids Research

    5 publications · 201 citations

    5

    h-index

  3. Chemistry & Biology

    2 publications · 303 citations

    2

    h-index

  4. Methods in enzymology on CD-ROM/Methods in enzymology

    Book series · 2 publications · 39 citations

    2

    h-index

  5. Analytical Biochemistry

    2 publications · 92 citations

    2

    h-index

1–5