Concepedia

Hexokinase Deficiency

Hexokinase Deficiency is a rare inherited metabolic disorder characterized by a deficiency in the hexokinase enzyme, which impairs the first step of glycolysis and leads to abnormal glucose metabolism in red blood cells and other tissues.

92

Publications

6.4K

Citations

431

Authors

181

Institutions

Publications per year

2017–2026

11

Parents

Publications

92

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

Krushna C. Patra, Qi Wang, Prashanth T. Bhaskar et al. · Cancer Cell · 2013 · 859 citations · Full text

, , +17

Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin

Dannielle C. DeWaal, Véronique Nogueira, Alexander R. Terry et al. · Nature Communications · 2018 · 558 citations · Full text

, , +17

Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

Douglas L. Rothman, I Magnusson, Gary W. Cline et al. · Proceedings of the National Academy of Sciences · 1995 · 326 citations

, , +17

Involvement of kinases in glucose and fructose uptake by Saccharomyces cerevisiae.

Linda F. Bisson, D G Fraenkel · Proceedings of the National Academy of Sciences · 1983 · 317 citations · Full text

, , +11

Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

Shaida A. Andrabi, George K. E. Umanah, Calvin Chang et al. · Proceedings of the National Academy of Sciences · 2014 · 313 citations · Full text

, , +15

1–5 of 92

Authors

431

  1. MM
    Mauro Magnani

    University of Urbino, Italy

    8 publications · 202 citations

    8

    h-index

  2. GF
    G Fornaini

    University of Urbino, Italy

    5 publications · 113 citations

    5

    h-index

  3. GR
    Gert Rijksen

    Utrecht University, Netherlands

    5 publications · 149 citations

    5

    h-index

  4. GE
    G. E. J. Staal

    Utrecht University, Netherlands

    4 publications · 104 citations

    4

    h-index

  5. EB
    Ernest Beutler

    City Of Hope National Medical Center, United States

    4 publications · 147 citations

    4

    h-index

1–5 of 431

Institutions

181

  1. University of Urbino

    Urbino, Italy

    8 h-index

    37 publications

    894 citations

  2. University Medical Center Utrecht

    Utrecht, The Netherlands

    5 h-index

    18 publications

    402 citations

  3. Harvard University

    Cambridge, United States

    4 h-index

    13 publications

    1.4K citations

  4. Utrecht University

    Utrecht, The Netherlands

    4 h-index

    12 publications

    336 citations

  5. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    5 publications

    520 citations

  6. University of Amsterdam

    Amsterdam, The Netherlands

    3 h-index

    5 publications

    371 citations

  7. City Of Hope National Medical Center

    Duarte, United States

    3 h-index

    7 publications

    262 citations

  8. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    13 publications

    1.3K citations

1–8 of 181

Venues

  1. Blood

    11 publications · 327 citations

    11

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 1.1K citations

    4

    h-index

  3. Journal of Clinical Investigation

    JCI · 4 publications · 203 citations

    4

    h-index

  4. British Journal of Haematology

    BJH · 3 publications · 57 citations

    3

    h-index

  5. Journal of Bacteriology

    JB · 3 publications · 90 citations

    3

    h-index

1–5