Concepedia

Hepatic Function-based Dose Adjustment

Hepatic Function-Based Dose Adjustment is a dose modification strategy that systematically alters drug dosage according to the degree of hepatic impairment, as assessed by clinical markers of liver function, to optimize therapeutic efficacy and minimize toxicity in patients with compromised liver function.

15

Publications

1.3K

Citations

83

Authors

43

Institutions

Publications per year

2017–2026

5

Parents

Publications

15

Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction

Roger K. Verbeeck · European Journal of Clinical Pharmacology · 2008 · 638 citations

, , +14

Individualized Adaptive Stereotactic Body Radiotherapy for Liver Tumors in Patients at High Risk for Liver Damage

Mary Feng, Krithika Suresh, Matthew J. Schipper et al. · JAMA Oncology · 2017 · 166 citations

, , +17

Etoposide pharmacokinetics in patients with normal and abnormal organ function.

Susan G. Arbuck, H. O. Douglass, W R Crom et al. · Journal of Clinical Oncology · 1986 · 96 citations

, , +17

Pharmacokinetics of linagliptin in subjects with hepatic impairment

Ulrike Graefe‐Mody, Peter W. Rose, Silke Retlich et al. · British Journal of Clinical Pharmacology · 2012 · 77 citations · Full text

, , +17

Dose adjustment in patients with liver cirrhosis: impact on adverse drug reactions and hospitalizations

Carmen C. Franz, Carole Hildbrand, Christa Born et al. · European Journal of Clinical Pharmacology · 2013 · 64 citations · Full text

, , +16

1–5 of 15

Authors

83

  1. PW
    Peter W. Rose

    University of Oxford, United Kingdom

    1 publications · 77 citations

    1

    h-index

  2. ND
    Neehar D. Parikh

    University of Michigan, United States

    1 publications · 166 citations

    1

    h-index

  3. FC
    Frédéric Cotton

    Université Libre de Bruxelles, Belgium

    1 publications · 19 citations

    1

    h-index

  4. BC
    Bonaventura Clotet

    Hospital Universitari Germans Trias i Pujol, Spain

    1 publications · 17 citations

    1

    h-index

  5. AC
    Angela Cisneros

    Northwestern University, United States

    1 publications · 23 citations

    1

    h-index

1–5 of 83

Institutions

43

  1. University of California, San Francisco

    San Francisco, United States

    2 h-index

    5 publications

    258 citations

  2. Research Triangle Park Foundation

    Durham, United States

    1 h-index

    3 publications

    51 citations

  3. Université Libre de Bruxelles

    Brussels, Belgium

    1 h-index

    1 publications

    19 citations

  4. Churchill Hospital

    Oxford, United Kingdom

    1 h-index

    2 publications

    26 citations

  5. University of Pennsylvania

    Philadelphia, United States

    1 h-index

    1 publications

    166 citations

  6. Délégation Paris 7

    Bagnolet, France

    1 h-index

    1 publications

    19 citations

  7. Ann Arbor VA Medical Center

    Ann Arbor, United States

    1 h-index

    7 publications

    1.2K citations

  8. Kishokai Medical Corporation

    Nagoya, Japan

    1 h-index

    2 publications

    74 citations

1–8 of 43

Venues

  1. European Journal of Clinical Pharmacology

    2 publications · 702 citations

    2

    h-index

  2. British Journal of Clinical Pharmacology

    BJCP · 1 publications · 77 citations

    1

    h-index

  3. Journal of Clinical Oncology

    1 publications · 96 citations

    1

    h-index

  4. JAMA Oncology

    1 publications · 166 citations

    1

    h-index

  5. British Journal of Cancer

    BJC · 1 publications · 13 citations

    1

    h-index

1–5