Concepedia

Helicase-driven Unwinding

Helicase-Driven Unwinding is a molecular mechanism in nucleic acid dynamics whereby the enzyme helicase catalyzes the separation of double-stranded DNA or RNA into single strands through ATP-dependent translocation along the nucleic acid backbone, distinguishing it from passive or protein-independent unwinding processes.

257

Publications

19.5K

Citations

670

Authors

253

Institutions

Publications per year

2017–2026

34

Parents

Publications

257

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

Florence Rozen, Isaac Edery, Karen Meerovitch et al. · Molecular and Cellular Biology · 1990 · 621 citations · Full text

, , +17

Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

Joseph L. Kim, Kurt Morgenstern, James P Griffith et al. · Structure · 1998 · 613 citations · Full text

, , +14

The Bloom's Syndrome Helicase Unwinds G4 DNA

Hui Sun, Julia Karow, Ian D. Hickson et al. · Journal of Biological Chemistry · 1998 · 532 citations · Full text

, , +16

UvrD Helicase Unwinds DNA One Base Pair at a Time by a Two-Part Power Stroke

Jae Young Lee, Wei Yang · Cell · 2006 · 390 citations · Full text

, , +9

RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP

Sophie Dumont, Wei Cheng, Victor Serebrov et al. · Nature · 2006 · 359 citations · Full text

, , +16

1–5 of 257

Authors

670

  1. KD
    Kevin D. Raney

    University of Arkansas for Medical Sciences, United States

    19 publications · 930 citations

    18

    h-index

  2. TM
    Timothy M. Lohman

    Washington University in St. Louis, United States

    17 publications · 1.5K citations

    15

    h-index

  3. SS
    Smita S. Patel

    Johnson University, United States

    14 publications · 1.2K citations

    14

    h-index

  4. RT
    Renu Tuteja

    International Centre for Genetic Engineering and Biotechnology, India

    10 publications · 738 citations

    10

    h-index

  5. SD
    Shuo‐Xing Dou

    Institute of Physics, China

    9 publications · 338 citations

    9

    h-index

1–5 of 670

Institutions

253

  1. University of Arkansas for Medical Sciences

    Little Rock, United States

    16 h-index

    65 publications

    3.1K citations

  2. Washington University in St. Louis

    St Louis, United States

    16 h-index

    47 publications

    3.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    29 publications

    4.3K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    60 publications

    2.8K citations

  5. Chinese Academy of Sciences

    Beijing, China

    11 h-index

    65 publications

    2.2K citations

  6. Institute of Physics

    Beijing, China

    10 h-index

    53 publications

    1.8K citations

  7. Pennsylvania State University

    State College, United States

    10 h-index

    24 publications

    1.5K citations

  8. Case Western Reserve University

    Cleveland, United States

    10 h-index

    29 publications

    7.8K citations

1–8 of 253

Venues

  1. Journal of Biological Chemistry

    JBC · 61 publications · 4.9K citations

    45

    h-index

  2. Nucleic Acids Research

    40 publications · 1.8K citations

    26

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 26 publications · 1.9K citations

    20

    h-index

  4. Biochemistry

    17 publications · 820 citations

    17

    h-index

  5. Journal of Molecular Biology

    JMB · 12 publications · 656 citations

    11

    h-index

1–5