Concepedia

Genetic Code Orthogonality

Genetic Code Orthogonality is a biochemical design principle in synthetic biology whereby engineered genetic codes operate independently of natural genetic systems, enabling the exclusive decoding of non-canonical amino acids without cross-reactivity with endogenous translational machinery.

45

Publications

3.8K

Citations

193

Authors

78

Institutions

Publications per year

2017–2026

26

Parents

Publications

45

Addition of a photocrosslinking amino acid to the genetic code of <i>Escherichia</i> <i>coli</i>

Jason W. Chin, Andrew Martin, David S. King et al. · Proceedings of the National Academy of Sciences · 2002 · 735 citations · Full text

, , +14

Adding Amino Acids with Novel Reactivity to the Genetic Code of <i>Saccharomyces Cerevisiae</i>

Alexander Deiters, T. Ashton Cropp, Mridul Mukherji et al. · Journal of the American Chemical Society · 2003 · 383 citations

, , +16

Addition of the keto functional group to the genetic code of <i>Escherichia</i> <i>coli</i>

Lei Wang, Zhiwen Zhang, Ansgar Brock et al. · Proceedings of the National Academy of Sciences · 2002 · 352 citations · Full text

, , +15

An expanded genetic code with a functional quadruplet codon

J. Christopher Anderson, Ning Wu, Stephen W. Santoro et al. · Proceedings of the National Academy of Sciences · 2004 · 323 citations · Full text

, , +13

Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair

Susan M. Hancock, Rajendra Uprety, Alexander Deiters et al. · Journal of the American Chemical Society · 2010 · 220 citations · Full text

, , +15

1–5 of 45

Authors

193

  1. JW
    Jason W. Chin

    MRC Laboratory of Molecular Biology, United Kingdom

    6 publications · 1.5K citations

    6

    h-index

  2. PG
    Peter G. Schultz

    Scripps Research Institute, United States

    5 publications · 2K citations

    5

    h-index

  3. AD
    Andrew D. Ellington

    The University of Texas at Austin, United States

    5 publications · 234 citations

    5

    h-index

  4. NB
    Nediljko Budiša

    Technische Universität Berlin, Germany

    4 publications · 121 citations

    4

    h-index

  5. JC
    J. Christopher Anderson

    University of California, Berkeley, United States

    3 publications · 734 citations

    3

    h-index

1–5 of 193

Institutions

78

  1. Scripps Research Institute

    San Diego, United States

    6 h-index

    28 publications

    10.4K citations

  2. The University of Texas at Austin

    Austin, United States

    5 h-index

    20 publications

    859 citations

  3. Technische Universität Berlin

    Berlin, Germany

    4 h-index

    9 publications

    254 citations

  4. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    4 h-index

    12 publications

    1.5K citations

  5. Yale University

    New Haven, United States

    4 h-index

    12 publications

    265 citations

  6. Medical Research Council

    London, United Kingdom

    3 h-index

    9 publications

    1.3K citations

  7. Colorado State University

    Fort Collins, United States

    2 h-index

    6 publications

    117 citations

  8. University of California, Berkeley

    Berkeley, United States

    2 h-index

    7 publications

    2K citations

1–8 of 78

Venues

  1. Journal of the American Chemical Society

    JACS · 5 publications · 903 citations

    5

    h-index

  2. Nucleic Acids Research

    5 publications · 241 citations

    5

    h-index

  3. ACS Synthetic Biology

    4 publications · 137 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 1.4K citations

    3

    h-index

  5. Biochemistry

    2 publications · 33 citations

    2

    h-index

1–5