Concepedia

Gene Copy Number Optimization

Gene Copy Number Optimization is a molecular engineering strategy that involves adjusting the number of copies of a target gene within a host organism’s genome to maximize the expression level and yield of a desired enzyme while maintaining cellular viability and metabolic balance.

47

Publications

3K

Citations

239

Authors

90

Institutions

Publications per year

2017–2026

18

Parents

Publications

47

Mapping of picoeucaryotes in marine ecosystems with quantitative PCR of the 18S rRNA gene

Fei Zhu, Ramón Massana, Fabrice Not et al. · FEMS Microbiology Ecology · 2004 · 651 citations

, , +11

Enhancement of protein secretion in <i>Pichia pastoris</i> by overexpression of protein disulfide isomerase

Mehmet İnan, Dinesh Aryasomayajula, Jayanta Sinha et al. · Biotechnology and Bioengineering · 2005 · 188 citations

, , +16

Cocktail δ-integration: a novel method to construct cellulolytic enzyme expression ratio-optimized yeast strains

Ryosuke Yamada, Naho Taniguchi, Tsutomu Tanaka et al. · Microbial Cell Factories · 2010 · 161 citations · Full text

, , +16

Efficient generation of multi-copy strains for optimizing secretory expression of porcine insulin precursor in yeast<i>Pichia pastoris</i>

Taicheng Zhu, Meijin Guo, Zhuo Tang et al. · Journal of Applied Microbiology · 2009 · 119 citations

, , +15

Towards quantitative metabarcoding of eukaryotic plankton: an approach to improve 18S rRNA gene copy number bias

Jon Lapeyra Martin, Ioulia Santi, Paraskevi Pitta et al. · Metabarcoding and Metagenomics · 2022 · 103 citations · Full text

, , +13

1–5 of 47

Authors

239

  1. LJ
    Liangcheng Jiao

    Huazhong University of Science and Technology, China

    2 publications · 48 citations

    2

    h-index

  2. ZS
    Zhixin Su

    Huazhong University of Science and Technology, China

    2 publications · 48 citations

    2

    h-index

  3. YY
    Yunjun Yan

    Huazhong University of Science and Technology, China

    2 publications · 48 citations

    2

    h-index

  4. QZ
    Qinghua Zhou

    Huazhong University of Science and Technology, China

    2 publications · 48 citations

    2

    h-index

  5. PG
    Pengfei Gu

    Shanghai Jiao Tong University, China

    1 publications · 78 citations

    1

    h-index

1–5 of 239

Institutions

90

  1. University of Colorado Boulder

    Boulder, United States

    2 h-index

    3 publications

    97 citations

  2. Shandong University

    Jinan, China

    2 h-index

    14 publications

    644 citations

  3. Huazhong University of Science and Technology

    Wuhan, China

    2 h-index

    9 publications

    222 citations

  4. Korea Advanced Institute of Science and Technology

    Daejeon, South Korea

    2 h-index

    2 publications

    114 citations

  5. University of Illinois Urbana-Champaign

    Urbana, United States

    2 h-index

    5 publications

    291 citations

  6. Baylor College of Medicine

    Houston, United States

    1 h-index

    5 publications

    220 citations

  7. Ege University

    Izmir, Türkiye

    1 h-index

    3 publications

    39 citations

  8. Rutgers, The State University of New Jersey

    New Brunswick, United States

    1 h-index

    4 publications

    108 citations

1–8 of 90

Venues

  1. Biotechnology and Bioengineering

    5 publications · 432 citations

    5

    h-index

  2. Applied Microbiology and Biotechnology

    3 publications · 138 citations

    3

    h-index

  3. ACS Synthetic Biology

    2 publications · 127 citations

    2

    h-index

  4. Biochemical and Biophysical Research Communications

    BBRC · 2 publications · 64 citations

    2

    h-index

  5. BMC Biotechnology

    2 publications · 96 citations

    2

    h-index

1–5