Concepedia

Framework Region Analysis

Framework Region Analysis is a computational immunoinformatic method that identifies and characterizes the conserved structural scaffold regions within antibody variable domains to distinguish them from hypervariable complementarity-determining regions, thereby enabling accurate prediction of antigen-binding properties and optimization of antibody engineering.

33

Publications

1.6K

Citations

149

Authors

75

Institutions

Publications per year

2017–2026

3

Variants

Fr Analysis

Parents

Publications

33

Comparative analysis of nanobody sequence and structure data

L. Mitchell, Lucy J. Colwell · Proteins Structure Function and Bioinformatics · 2018 · 235 citations · Full text

, , +17

Evidence for Involvement of a Hydrophobic Patch in Framework Region 1 of Human V4-34-Encoded Igs in Recognition of the Red Blood Cell I Antigen

Kathleen N. Potter, Paul Hobby, Susanne Klijn et al. · The Journal of Immunology · 2002 · 110 citations · Full text

, , +17

Model-building Studies of Antigen-binding Sites: The Hapten-binding Site of MOPC-315

Eduardo A. Padlan, D.R. Davies, Israel Pecht et al. · Cold Spring Harbor Symposia on Quantitative Biology · 1977 · 84 citations

, , +17

Predicting Regional Mutability in Antibody V Genes Based Solely on Di- and Trinucleotide Sequence Composition

Gary S. Shapiro, Katja Aviszus, David Iklé et al. · The Journal of Immunology · 1999 · 81 citations · Full text

, , +16

Molecular Analysis of Immunoglobulin Genes in Primary Intraocular Lymphoma

Sarah E. Coupland, Michael Hummel, Hans-Henning Mu ̈ller et al. · Investigative Ophthalmology & Visual Science · 2005 · 80 citations · Full text

, , +17

1–5 of 33

Authors

149

  1. AS
    Alan Solomon

    University of Tennessee at Knoxville, United States

    2 publications · 110 citations

    2

    h-index

  2. DW
    Deborah Weiss

    University of Tennessee at Knoxville, United States

    2 publications · 52 citations

    2

    h-index

  3. KN
    Kathleen N. Potter

    The University of Western Australia, Australia

    2 publications · 134 citations

    2

    h-index

  4. MM
    Mary-Kate Morris

    California Department of Public Health, United States

    1 publications · 13 citations

    1

    h-index

  5. AM
    Atsuo Mikata

    Chiba University, Japan

    1 publications · 14 citations

    1

    h-index

1–5 of 149

Institutions

75

  1. University of Tennessee at Knoxville

    Knoxville, United States

    3 h-index

    12 publications

    604 citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    3 h-index

    7 publications

    224 citations

  3. National Institutes of Health

    Bethesda, United States

    2 h-index

    7 publications

    460 citations

  4. University of Tennessee Medical Center

    Knoxville, United States

    2 h-index

    6 publications

    142 citations

  5. National Institute of Arthritis and Musculoskeletal and Skin Diseases

    Bethesda, United States

    2 h-index

    7 publications

    460 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    8 publications

    487 citations

  7. Protein Research Foundation

    Osaka, Japan

    1 h-index

    1 publications

    36 citations

  8. Universitätsklinikum des Saarlandes

    Homburg, Germany

    1 h-index

    1 publications

    75 citations

1–8 of 75

Venues

  1. The Journal of Immunology

    JI · 14 publications · 591 citations

    13

    h-index

  2. mAbs

    2 publications · 62 citations

    2

    h-index

  3. Scandinavian Journal of Immunology

    2 publications · 54 citations

    2

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 117 citations

    2

    h-index

  5. Journal of Molecular Biology

    JMB · 2 publications · 103 citations

    2

    h-index

1–5