Concepedia

Fosfomycin Inactivation

Fosfomycin Inactivation is an enzymatic modification mechanism characterized by the stereospecific addition of a glutathione molecule to the epoxy ring of fosfomycin, thereby abolishing its antibacterial activity through covalent ring opening catalyzed by fosfomycin-resistant glutathione S-transferases.

35

Publications

1.8K

Citations

154

Authors

60

Institutions

Publications per year

2017–2026

5

Parents

Publications

35

Characterization of a Cys115 to Asp Substitution in the <i>Escherichia coli</i> Cell Wall Biosynthetic Enzyme UDP-GlcNAc Enolpyruvyl Transferase (MurA) That Confers Resistance to Inactivation by the Antibiotic Fosfomycin

Dennis H. Kim, Watson J. Lees, Karen E. Kempsell et al. · Biochemistry · 1996 · 195 citations

, , +17

Prevalence of Fosfomycin Resistance among CTX-M-Producing <i>Escherichia coli</i> Clinical Isolates in Japan and Identification of Novel Plasmid-Mediated Fosfomycin-Modifying Enzymes

Jun‐ichi Wachino, Kunikazu Yamane, Satowa Suzuki et al. · Antimicrobial Agents and Chemotherapy · 2010 · 150 citations · Full text

, , +17

Kinetics, Stoichiometry, and Identification of the Reactive Thiolate in the Inactivation of UDP-GlcNAc Enolpyruvoyl Transferase by the Antibiotic Fosfomycin

John L. Marquardt, Eric D. Brown, William S. Lane et al. · Biochemistry · 1994 · 144 citations

, , +17

The Glycerol-3-Phosphate Permease GlpT Is the Only Fosfomycin Transporter in <i>Pseudomonas aeruginosa</i>

Alfredo Castañeda-García, Alexandro Rodríguez-Rojas, Javier R. Guelfo et al. · Journal of Bacteriology · 2009 · 117 citations · Full text

, , +13

Fosfomycin therapy for multiresistant Pseudomonas aeruginosa in cystic fibrosis

Anirudh Mirakhur, Malcolm Gallagher, M.J. Ledson et al. · Journal of Cystic Fibrosis · 2003 · 73 citations · Full text

, , +15

1–5 of 35

Authors

154

  1. ES
    E. Schönbrunn

    Moffitt Cancer Center, United States

    3 publications · 126 citations

    3

    h-index

  2. NA
    Nikolaus Amrhein

    ETH Zurich, Switzerland

    2 publications · 59 citations

    2

    h-index

  3. MK
    Matthew K. Thompson

    North Carolina State University, United States

    2 publications · 74 citations

    2

    h-index

  4. MK
    M.E. Keithly

    Vanderbilt University, United States

    2 publications · 74 citations

    2

    h-index

  5. YY
    Yan Yang

    Moffitt Cancer Center, United States

    2 publications · 79 citations

    2

    h-index

1–5 of 154

Institutions

60

  1. Vanderbilt University

    Nashville, United States

    2 h-index

    12 publications

    504 citations

  2. Moffitt Cancer Center

    Tampa, United States

    2 h-index

    10 publications

    426 citations

  3. The University of Tokyo

    Tokyo, Japan

    2 h-index

    4 publications

    219 citations

  4. Harvard University

    Cambridge, United States

    2 h-index

    7 publications

    1.3K citations

  5. Universidad de Oviedo

    Oviedo, Spain

    2 h-index

    9 publications

    378 citations

  6. Guangdong University of Technology

    Guangzhou, China

    1 h-index

    6 publications

    126 citations

  7. Essex Cardiothoracic Centre

    Basildon, United Kingdom

    1 h-index

    4 publications

    292 citations

  8. Pingtung Hospital

    Pingtung City, Taiwan

    1 h-index

    1 publications

    41 citations

1–8 of 60

Venues

  1. Biochemistry

    6 publications · 559 citations

    6

    h-index

  2. Antimicrobial Agents and Chemotherapy

    AAC · 4 publications · 304 citations

    4

    h-index

  3. Journal of Bacteriology

    JB · 2 publications · 179 citations

    2

    h-index

  4. PubMed

    Repository · 2 publications · 81 citations

    2

    h-index

  5. The Journal of Physical Chemistry B

    1 publications · 13 citations

    1

    h-index

1–5