Concepedia

Fold Evolution

Fold Evolution is the evolutionary process by which protein folds—three-dimensional structural motifs—arise, diversify, and are conserved across proteins through modifications in amino acid sequences and structural rearrangements over time.

385

Publications

29K

Citations

1.2K

Authors

467

Institutions

Publications per year

2017–2026

63

Parents

Publications

385

The <i>α</i>/<i>β</i> hydrolase fold

David L. Ollis, Eong Cheah, Mirosław Cygler et al. · Protein Engineering Design and Selection · 1992 · 2.1K citations · Full text

, , +17

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

D. Allan Drummond, Claus O. Wilke · Cell · 2008 · 1.1K citations · Full text

, , +16

Evolution of function in protein superfamilies, from a structural perspective 1 1Edited by A. R. Fersht

Annabel E. Todd, Christine Orengo, Janet M. Thornton · Journal of Molecular Biology · 2001 · 695 citations

, , +15

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding

Sebastian Pechmann, Judith Frydman · Nature Structural & Molecular Biology · 2012 · 535 citations · Full text

, , +16

Predicting multiple conformations via sequence clustering and AlphaFold2

Hannah K. Wayment-Steele, Adedolapo Ojoawo, Renee Otten et al. · Nature · 2023 · 517 citations · Full text

, , +17

1–5 of 385

Authors

1.2K

  1. EI
    Eugene I. Shakhnovich

    Harvard University, United States

    10 publications · 646 citations

    10

    h-index

  2. AN
    Andrei N. Lupas

    Max Planck Institute for Developmental Biology, Germany

    10 publications · 826 citations

    10

    h-index

  3. MB
    Michael Blaber

    Florida State University, United States

    8 publications · 366 citations

    8

    h-index

  4. LL
    Lauren L. Porter

    National Heart Lung and Blood Institute, United States

    8 publications · 418 citations

    8

    h-index

  5. MC
    Matthew Cordes

    University of Arizona, United States

    7 publications · 405 citations

    7

    h-index

1–5 of 1.2K

Institutions

467

  1. National Institutes of Health

    Bethesda, United States

    18 h-index

    43 publications

    2.3K citations

  2. National Center for Biotechnology Information

    Bethesda, United States

    16 h-index

    36 publications

    3.3K citations

  3. Harvard University

    Cambridge, United States

    15 h-index

    45 publications

    5.2K citations

  4. Max Planck Institute for Developmental Biology

    Tübingen, Germany

    14 h-index

    74 publications

    4.6K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    14 h-index

    33 publications

    6.8K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    39 publications

    1.4K citations

  7. University of Haifa

    Haifa, Israel

    11 h-index

    20 publications

    689 citations

  8. University of Michigan

    Ann Arbor, United States

    11 h-index

    32 publications

    2.7K citations

1–8 of 467

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 41 publications · 3.6K citations

    33

    h-index

  2. Journal of Molecular Biology

    JMB · 29 publications · 3.6K citations

    25

    h-index

  3. Proteins Structure Function and Bioinformatics

    26 publications · 1.4K citations

    20

    h-index

  4. Protein Science

    PS · 22 publications · 868 citations

    16

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 12 publications · 2.7K citations

    12

    h-index

1–5