Concepedia

First-pass Metabolism Differences

First-Pass Metabolism Differences is a toxicokinetic phenomenon referring to interspecies variations in the extent and rate of drug metabolism that occur during the initial passage of an absorbed compound through the liver and gut wall before it reaches systemic circulation.

47

Publications

2.6K

Citations

179

Authors

68

Institutions

Publications per year

2017–2026

5

Parents

Publications

47

First pass metabolism of ethanol - A gastrointestinal barrier against the systematic toxicity of ethanol

Risto Julkunen, C. Di Padova, Charles S. Lieber · Life Sciences · 1985 · 197 citations

, , +14

Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration.

Michele C. Meyer, Arthur B. Straughn, Ming Lo et al. · PubMed · 1984 · 167 citations

, , +13

Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.

Jiunn H. Lin, Masato Chiba, Suresh K. Balani et al. · Drug Metabolism and Disposition · 1996 · 153 citations

, , +14

Preclinical pharmacokinetics of statins

J. Prous · Methods and Findings in Experimental and Clinical Pharmacology · 2002 · 152 citations

, , +15

First pass metabolism of ethanol: An important determinant of blood levels after alcohol consumption

Risto Julkunen, Laura Tannenbaum, Enrique Baraona et al. · Alcohol · 1985 · 127 citations

, , +13

1–5 of 47

Authors

179

  1. RJ
    Risto Julkunen

    Kuopio University Hospital, Finland

    2 publications · 324 citations

    2

    h-index

  2. MC
    Masato Chiba

    Kindai University, Japan

    2 publications · 236 citations

    2

    h-index

  3. JA
    Joy A. Nishime

    United States Military Academy, United States

    2 publications · 236 citations

    2

    h-index

  4. JH
    Jiunn H. Lin

    United States Military Academy, United States

    2 publications · 236 citations

    2

    h-index

  5. CS
    Charles S. Lieber

    Icahn School of Medicine at Mount Sinai, United States

    2 publications · 317 citations

    2

    h-index

1–5 of 179

Institutions

68

  1. Veterans Health Administration

    Washington D.C., United States

    2 h-index

    5 publications

    348 citations

  2. United States Department of Veterans Affairs

    Washington, United States

    2 h-index

    4 publications

    648 citations

  3. Icahn School of Medicine at Mount Sinai

    New York, United States

    2 h-index

    7 publications

    1.1K citations

  4. AstraZeneca (Sweden)

    Södertälje, Sweden

    2 h-index

    5 publications

    184 citations

  5. United States Military Academy

    West Point, United States

    2 h-index

    2 publications

    236 citations

  6. University of Göttingen

    Göttingen, Germany

    1 h-index

    2 publications

    84 citations

  7. University of Helsinki

    Helsinki, Finland

    1 h-index

    4 publications

    168 citations

  8. University of Alberta

    Edmonton, Canada

    1 h-index

    4 publications

    360 citations

1–8 of 68

Venues

  1. PubMed

    Repository · 6 publications · 317 citations

    6

    h-index

  2. Drug Metabolism and Disposition

    3 publications · 265 citations

    3

    h-index

  3. Clinical Pharmacology & Therapeutics

    CPT · 3 publications · 245 citations

    3

    h-index

  4. European Journal of Clinical Pharmacology

    2 publications · 43 citations

    2

    h-index

  5. 2

    h-index

1–5