Concepedia

First-pass Distribution

First-Pass Distribution is a pharmacokinetic phenomenon in which a drug, following oral administration, undergoes extensive distribution into and elimination from the liver before reaching systemic circulation, thereby significantly reducing its bioavailability.

25

Publications

1.1K

Citations

105

Authors

25

Institutions

Publications per year

2017–2026

0

Parents

Publications

25

Influence of First-Pass Effect on Availability of Drugs on Oral Administration

M. Gibaldi, R N Boyes, Stuart Feldman · Journal of Pharmaceutical Sciences · 1971 · 272 citations

, , +14

The systemic bioavailability of buprenorphine by various routes of administration

David Brewster, Michael Humphrey, M. A. McLeavy · Journal of Pharmacy and Pharmacology · 1981 · 98 citations

, , +15

Delivery of ultraviolet-inactivated 35S-herpesvirus across an osmotically modified blood-brain barrier

Edward A. Neuwelt, Michael A. Pagel, Richard D. Dix · Journal of neurosurgery · 1991 · 78 citations

, , +17

Amino acid use by the gastrointestinal tract of sheep given lucerne forage

John Macrae, L.A. Bruce, D. S. Brown et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 1997 · 75 citations

, , +13

Effect of portacaval shunt on the disposition of drugs with and without first-pass effect.

R Gugler, Pedro Lain, Daniel L. Azarnoff · Journal of Pharmacology and Experimental Therapeutics · 1975 · 73 citations

, , +16

1–5 of 25

Authors

105

  1. NJ
    N. Jeandidier

    Université de Strasbourg, France

    2 publications · 63 citations

    2

    h-index

  2. MA
    M. Arthur Charles

    University of California, Irvine, United States

    2 publications · 63 citations

    2

    h-index

  3. MG
    Myung G. Lee

    Seoul National University, South Korea

    2 publications · 91 citations

    2

    h-index

  4. YC
    Yu C. Kim

    Seoul National University, South Korea

    2 publications · 91 citations

    2

    h-index

  5. DB
    David Brewster

    Michigan State University, United States

    1 publications · 98 citations

    1

    h-index

1–5 of 105

Institutions

25

  1. Seoul National University

    Seoul, South Korea

    3 h-index

    8 publications

    336 citations

  2. University of Southern California

    Los Angeles, United States

    1 h-index

    6 publications

    318 citations

  3. Roche (Switzerland)

    Basel, Switzerland

    1 h-index

    2 publications

    102 citations

  4. La Roche College

    Pittsburgh, United States

    1 h-index

    2 publications

    102 citations

  5. University of Minnesota

    Minneapolis, United States

    1 h-index

    1 publications

    19 citations

  6. Reckitt Benckiser (United Kingdom)

    Slough, United Kingdom

    1 h-index

    3 publications

    294 citations

  7. Purdue University West Lafayette

    West Lafayette, United States

    1 h-index

    6 publications

    72 citations

  8. University of Illinois Chicago

    Chicago, United States

    1 h-index

    1 publications

    21 citations

1–8 of 25

Venues

  1. PubMed

    Repository · 3 publications · 50 citations

    3

    h-index

  2. 2

    h-index

  3. Journal of Pharmaceutical Sciences

    2 publications · 314 citations

    2

    h-index

  4. Drug Metabolism and Disposition

    2 publications · 41 citations

    2

    h-index

  5. Diabetes

    2 publications · 63 citations

    2

    h-index

1–5