Concepedia

Filament Structure Polymorphism

Filament Structure Polymorphism is a biophysical phenomenon characterized by the capacity of protein filaments, particularly in neurodegenerative diseases, to adopt multiple distinct three-dimensional conformations under identical environmental conditions, thereby giving rise to structurally heterogeneous fibrillar assemblies from a single polypeptide sequence.

64

Publications

5.4K

Citations

285

Authors

138

Institutions

Publications per year

2017–2026

16

Variants

Filament Polymorphism

Parents

Publications

64

Structures of α-synuclein filaments from multiple system atrophy

Manuel Schweighauser, Yang Shi, Airi Tarutani et al. · Nature · 2020 · 833 citations · Full text

, , +17

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

Wenjuan Zhang, Benjamin Falcon, Alexey G. Murzin et al. · eLife · 2019 · 531 citations · Full text

, , +17

Structures of α-synuclein filaments from human brains with Lewy pathology

Yang Yang, Yang Shi, Manuel Schweighauser et al. · Nature · 2022 · 487 citations · Full text

, , +16

Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

Ricardo Guerrero-Ferreira, Nicholas M. I. Taylor, Ana‐Andreea Arteni et al. · eLife · 2019 · 351 citations · Full text

, , +17

Human CTP synthase filament structure reveals the active enzyme conformation

Eric M. Lynch, Derrick R. Hicks, Matthew Shepherd et al. · Nature Structural & Molecular Biology · 2017 · 207 citations · Full text

, , +14

1–5 of 64

Authors

285

  1. AG
    Alexey G. Murzin

    MRC Laboratory of Molecular Biology, United Kingdom

    6 publications · 2.1K citations

    6

    h-index

  2. SH
    Sjors H. W. Scheres

    MRC Laboratory of Molecular Biology, United Kingdom

    6 publications · 2.1K citations

    6

    h-index

  3. MG
    Michel Goedert

    MRC Laboratory of Molecular Biology, United Kingdom

    6 publications · 2.1K citations

    6

    h-index

  4. BG
    Bernardino Ghetti

    Indiana University – Purdue University Indianapolis, United States

    4 publications · 1.5K citations

    4

    h-index

  5. KH
    Kazuko Hasegawa

    National Sagamihara Hospital, Japan

    3 publications · 1.4K citations

    3

    h-index

1–5 of 285

Institutions

138

  1. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    8 h-index

    41 publications

    12.9K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    24 publications

    2.3K citations

  3. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    4 h-index

    9 publications

    3.1K citations

  4. National Institutes of Health

    Bethesda, United States

    4 h-index

    10 publications

    801 citations

  5. Max Planck Institute for Biophysical Chemistry

    Göttingen, Germany

    4 h-index

    12 publications

    704 citations

  6. Indiana University School of Medicine

    Indianapolis, United States

    4 h-index

    9 publications

    3.1K citations

  7. Nagoya University

    Nagoya, Japan

    4 h-index

    11 publications

    1.2K citations

  8. Max Planck Society

    Munich, Germany

    4 h-index

    10 publications

    615 citations

1–8 of 138

Venues

  1. Journal of Molecular Biology

    JMB · 12 publications · 844 citations

    12

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 149 citations

    3

    h-index

  3. Experimental Cell Research

    ECR · 3 publications · 82 citations

    3

    h-index

  4. eLife

    2 publications · 882 citations

    2

    h-index

  5. Journal of Biological Chemistry

    JBC · 2 publications · 114 citations

    2

    h-index

1–5