Concepedia

Epistatic Constraint

Epistatic Constraint is a theoretical construct in evolutionary biology that designates the limitation on the adaptive trajectory of a population imposed by the nonlinear interactions between genetic loci, whereby the phenotypic effect of a mutation at one locus depends on the genetic state at another, thereby constraining the accessibility and ordering of beneficial mutations in genotype space.

75

Publications

8.1K

Citations

276

Authors

138

Institutions

Publications per year

2017–2026

13

Parents

Publications

75

The Molecular Diversity of Adaptive Convergence

Olivier Tenaillon, Alejandra Rodríguez‐Verdugo, Rebecca L. Gaut et al. · Science · 2012 · 885 citations

, , +17

PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES

Daniel Weinreich, Richard A. Watson, Lin Chao · Evolution · 2005 · 583 citations

, , +17

Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

Hsin-Hung Chou, Hsuan-Chao Chiu, Nigel F. Delaney et al. · Science · 2011 · 573 citations · Full text

, , +14

Epistasis and the Evolutionary Process

Laurence D. Hurst · Heredity · 2000 · 564 citations

, , +10

Perspective: Sign epistasis and genetic constraint on evolutionary trajectories.

Daniel Weinreich, Richard A. Watson · PubMed · 2005 · 402 citations

, , +17

1–5 of 75

Authors

276

  1. GP
    Günter P. Wagner

    Yale University, United States

    3 publications · 101 citations

    3

    h-index

  2. DW
    Daniel Weinreich

    University of Maryland, Baltimore, United States

    2 publications · 704 citations

    2

    h-index

  3. CC
    Călin C. Guet

    Institute of Science and Technology Austria, Austria

    2 publications · 60 citations

    2

    h-index

  4. ML
    Mato Lagator

    Institute of Science and Technology Austria, Austria

    2 publications · 60 citations

    2

    h-index

  5. ÖC
    Örjan Carlborg

    Swedish University of Agricultural Sciences, Sweden

    2 publications · 318 citations

    2

    h-index

1–5 of 276

Institutions

138

  1. Yale University

    New Haven, United States

    4 h-index

    6 publications

    326 citations

  2. University of Georgia

    Athens, United States

    3 h-index

    13 publications

    1.4K citations

  3. University of British Columbia

    Vancouver, Canada

    3 h-index

    6 publications

    102 citations

  4. Harvard University

    Cambridge, United States

    3 h-index

    6 publications

    2.9K citations

  5. Michigan State University

    East Lansing, United States

    3 h-index

    6 publications

    336 citations

  6. Cornell University

    Ithaca, United States

    2 h-index

    12 publications

    462 citations

  7. Stanford University

    Stanford, United States

    2 h-index

    5 publications

    257 citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    4 publications

    323 citations

1–8 of 138

Venues

  1. Genetics

    7 publications · 594 citations

    7

    h-index

  2. Evolution

    5 publications · 672 citations

    5

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 360 citations

    4

    h-index

  4. PLoS Genetics

    4 publications · 429 citations

    4

    h-index

  5. Journal of Theoretical Biology

    3 publications · 52 citations

    3

    h-index

1–5