Concepedia

Epimerization Domains

Epimerization Domain is a catalytic domain within nonribosomal peptide synthetase modules that mediates the stereochemical inversion of an amino acid residue by converting its L-form to the D-form, thereby introducing structural diversity into the growing peptide chain.

84

Publications

5.5K

Citations

386

Authors

117

Institutions

Publications per year

2017–2026

21

Parents

Publications

84

Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution

Christian Rausch, Ilka Hoof, Tilmann Weber et al. · BMC Evolutionary Biology · 2007 · 337 citations · Full text

, , +13

The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains

Henning D. Mootz, Mohamed A. Marahiel · Journal of Bacteriology · 1997 · 303 citations

, , +14

Genetic Analysis of the Peptide Synthetase Genes for a Cyclic Heptapeptide Microcystin in Microcystis spp.

Tatsuo NISHIZAWA, Munehiko Asayama, Kiyonaga Fujii et al. · The Journal of Biochemistry · 1999 · 261 citations

, , +13

The structure of VibH represents nonribosomal peptide synthetase condensation, cyclization and epimerization domains

Thomas A. Keating, C. Gary Marshall, Christopher T. Walsh et al. · Nature Structural Biology · 2002 · 234 citations

, , +14

Studies of the Reversible Epimerization Occurring in the Tetracycline Family. The Preparation, Properties and Proof of Structure of Some 4-epi-Tetracyclines

J. R. D. McCormick, Sidney M. Fox, Leland L. Smith et al. · Journal of the American Chemical Society · 1957 · 194 citations

, , +9

1–5 of 84

Authors

386

  1. MA
    Mohamed A. Marahiel

    Philipps University of Marburg, Germany

    10 publications · 1.1K citations

    10

    h-index

  2. CT
    Christopher T. Walsh

    Harvard University, United States

    8 publications · 877 citations

    8

    h-index

  3. UL
    Uwe Linne

    Philipps University of Marburg, Germany

    6 publications · 500 citations

    6

    h-index

  4. CK
    Chaitan Khosla

    Stanford University, United States

    3 publications · 85 citations

    3

    h-index

  5. DE
    David E. Cane

    Brown University, United States

    3 publications · 85 citations

    3

    h-index

1–5 of 386

Institutions

117

  1. Philipps University of Marburg

    Marburg, Germany

    11 h-index

    37 publications

    3.5K citations

  2. Harvard University

    Cambridge, United States

    8 h-index

    27 publications

    2.8K citations

  3. University of Wisconsin–Madison

    Madison, United States

    5 h-index

    11 publications

    415 citations

  4. Hokkaido University

    Sapporo, Japan

    3 h-index

    16 publications

    886 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    18 publications

    734 citations

  6. University of Cambridge

    Cambridge, United Kingdom

    3 h-index

    14 publications

    1.3K citations

  7. Stanford University

    Stanford, United States

    3 h-index

    3 publications

    85 citations

  8. Brown University

    Providence, United States

    3 h-index

    8 publications

    226 citations

1–8 of 117

Venues

  1. Biochemistry

    11 publications · 858 citations

    11

    h-index

  2. Journal of the American Chemical Society

    JACS · 9 publications · 536 citations

    9

    h-index

  3. Journal of Biological Chemistry

    JBC · 8 publications · 592 citations

    8

    h-index

  4. Journal of Bacteriology

    JB · 6 publications · 745 citations

    6

    h-index

  5. ACS Chemical Biology

    5 publications · 316 citations

    5

    h-index

1–5