Concepedia

Enzyme Target Profiling

Enzyme Target Profiling is a systematic analytical framework used in biochemistry and pharmacology that identifies and characterizes the spectrum of enzymatic targets modulated by a bioactive compound, thereby distinguishing its functional interactions within complex biological systems.

23

Publications

1.3K

Citations

124

Authors

38

Institutions

Publications per year

2017–2026

7

Parents

Publications

23

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

Gregory C. Adam, Erik J. Sorensen, Benjamin F. Cravatt · Nature Biotechnology · 2002 · 227 citations

, , +16

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras‐Signaling Modulators Palmostatin B and M

Marion Rusch, Tobias J. Zimmermann, Marco Bürger et al. · Angewandte Chemie International Edition · 2011 · 124 citations

, , +17

A Selenium‐Based Click AdoMet Analogue for Versatile Substrate Labeling with Wild‐Type Protein Methyltransferases

Sophie Willnow, Michael G. Martin, Bernhard Lüscher et al. · ChemBioChem · 2012 · 112 citations · Full text

, , +17

Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics

Jonathan B. Olsen, Xing-Jun Cao, Bomie Han et al. · Molecular & Cellular Proteomics · 2016 · 103 citations · Full text

, , +17

Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling

Rhushikesh A. Kulkarni, Andrew J. Worth, Thomas Zengeya et al. · Cell chemical biology · 2017 · 101 citations · Full text

, , +14

1–5 of 23

Authors

124

  1. SA
    Stephan A. Sieber

    Technical University of Munich, Germany

    4 publications · 250 citations

    4

    h-index

  2. GA
    Gijs A. van der Marel

    Leiden University, Netherlands

    3 publications · 94 citations

    3

    h-index

  3. HS
    Herman S. Overkleeft

    Leiden University, Netherlands

    3 publications · 94 citations

    3

    h-index

  4. AB
    Andreas Brockmeyer

    Max Planck Institute of Molecular Physiology, Germany

    2 publications · 140 citations

    2

    h-index

  5. CH
    Christian Hedberg

    Max Planck Institute of Molecular Physiology, Germany

    2 publications · 140 citations

    2

    h-index

1–5 of 124

Institutions

38

  1. Leiden University

    Leiden, The Netherlands

    4 h-index

    25 publications

    796 citations

  2. Technical University of Munich

    Munich, Germany

    4 h-index

    11 publications

    645 citations

  3. Scripps Research Institute

    San Diego, United States

    3 h-index

    6 publications

    842 citations

  4. TU Dortmund University

    Dortmund, Germany

    2 h-index

    16 publications

    1.1K citations

  5. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    2 h-index

    20 publications

    1.4K citations

  6. Center for Integrated Protein Science Munich

    Munich, Germany

    2 h-index

    7 publications

    365 citations

  7. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    5 publications

    509 citations

  8. University of Groningen

    Groningen, The Netherlands

    2 h-index

    2 publications

    140 citations

1–8 of 38

Venues

  1. Angewandte Chemie International Edition

    3 publications · 248 citations

    3

    h-index

  2. Angewandte Chemie

    2 publications · 31 citations

    2

    h-index

  3. Pest Management Science

    2 publications · 31 citations

    2

    h-index

  4. Molecular & Cellular Proteomics

    MCP · 2 publications · 167 citations

    2

    h-index

  5. Nature Biotechnology

    1 publications · 227 citations

    1

    h-index

1–5