Concepedia

Enzyme Substrate Binding Orientation

Enzyme Substrate Binding Orientation is a biochemical interaction model that specifies the spatial arrangement and directional alignment of a substrate relative to the active site of an enzyme during catalytic binding, distinguishing it from other binding modes by its emphasis on stereospecificity and molecular complementarity.

134

Publications

8.9K

Citations

560

Authors

196

Institutions

Publications per year

2017–2026

15

Parents

Publications

134

Defining the Human Deubiquitinating Enzyme Interaction Landscape

Mathew E. Sowa, Eric J. Bennett, Steven P. Gygi et al. · Cell · 2009 · 1.6K citations · Full text

, , +12

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

Mikko Taipale, Irina Krykbaeva, Martina Koeva et al. · Cell · 2012 · 903 citations · Full text

, , +16

Binding of chloromethyl ketone substrate analogs to crystalline papain

Joost P.H. Drenth, K.H. Kalk, H.M. Swen · Biochemistry · 1976 · 356 citations

, , +17

Glucose-induced conformational change in yeast hexokinase.

William S. Bennett, T.A. Steitz · Proceedings of the National Academy of Sciences · 1978 · 305 citations

, , +17

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

Brian C. Monk, Thomas Tomasiak, Mikhail V. Keniya et al. · Proceedings of the National Academy of Sciences · 2014 · 281 citations · Full text

, , +17

1–5 of 134

Authors

560

  1. RH
    Russ Hille

    The Ohio State University, United States

    5 publications · 480 citations

    4

    h-index

  2. HK
    Hartmut Kühn

    Charité - Universitätsmedizin Berlin, Germany

    3 publications · 74 citations

    3

    h-index

  3. JM
    James M. Pauff

    The Ohio State University, United States

    3 publications · 330 citations

    3

    h-index

  4. HC
    Hongnan Cao

    University of Wisconsin–Madison, United States

    3 publications · 283 citations

    3

    h-index

  5. KS
    Kristin Schwarz

    Charité - Universitätsmedizin Berlin, Germany

    2 publications · 64 citations

    2

    h-index

1–5 of 560

Institutions

196

  1. University of California, Riverside

    Riverside, United States

    4 h-index

    11 publications

    1K citations

  2. The Ohio State University

    Columbus, United States

    4 h-index

    14 publications

    964 citations

  3. Brandeis University

    Waltham, United States

    3 h-index

    15 publications

    1.3K citations

  4. ETH Zurich

    Zurich, Switzerland

    3 h-index

    9 publications

    208 citations

  5. University of Freiburg

    Freiburg im Breisgau, Germany

    3 h-index

    6 publications

    377 citations

  6. University of New Mexico

    Albuquerque, United States

    3 h-index

    14 publications

    965 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    17 publications

    809 citations

  8. University of Toronto

    Toronto, Canada

    3 h-index

    7 publications

    413 citations

1–8 of 196

Venues

  1. Biochemistry

    22 publications · 1.4K citations

    19

    h-index

  2. Journal of Biological Chemistry

    JBC · 12 publications · 736 citations

    11

    h-index

  3. Journal of Molecular Biology

    JMB · 7 publications · 406 citations

    7

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 954 citations

    5

    h-index

  5. Journal of the American Chemical Society

    JACS · 4 publications · 263 citations

    4

    h-index

1–5