Concepedia

Enzyme Saturation Models

Enzyme Saturation Models is a class of nonlinear pharmacokinetic models that describe drug metabolism kinetics by accounting for the saturation of enzymatic capacity, distinguishing it from linear models through its incorporation of Michaelis-Menten dynamics to represent finite enzyme binding and turnover rates.

43

Publications

3.4K

Citations

137

Authors

68

Institutions

Publications per year

2017–2026

0

Variants

Michaelis-menten Pharmacokinetic Models

Parents

Publications

43

A Comparison of Estimates of Michaelis-Menten Kinetic Constants from Various Linear Transformations

John E. Dowd, Douglas S. Riggs · Journal of Biological Chemistry · 1965 · 1.1K citations · Full text

, , +16

How to analyze binding, enzyme and uptake data: The simplest case, a single phase

Justin A. Zivin, D. R. Waud · Life Sciences · 1982 · 261 citations

, , +15

The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization

Avi I. Flamholz, Arren Bar‐Even, Dan Davidi et al. · PLoS Computational Biology · 2016 · 217 citations · Full text

, , +13

Significance of intermediary plateau regions in enzyme saturation curves

John W. Teipel, Daniel E. Koshland · Biochemistry · 1969 · 184 citations

, , +11

Towards kinetic modeling of genome‐scale metabolic networks without sacrificing stoichiometric, thermodynamic and physiological constraints

Anirikh Chakrabarti, Ljubiša Mišković, Keng Cher Soh et al. · Biotechnology Journal · 2013 · 165 citations · Full text

, , +16

1–5 of 43

Authors

137

  1. DR
    D. R. Waud

    University of Massachusetts Chan Medical School, United States

    2 publications · 271 citations

    2

    h-index

  2. JA
    Justin A. Zivin

    University of California San Diego, United States

    2 publications · 271 citations

    2

    h-index

  3. RC
    Richard Cotton

    Met Office, United Kingdom

    1 publications · 113 citations

    1

    h-index

  4. AR
    Alan Richens

    University of Wales, United Kingdom

    1 publications · 22 citations

    1

    h-index

  5. LV
    Liisa van Vliet

    University of Cambridge, United Kingdom

    1 publications · 44 citations

    1

    h-index

1–5 of 137

Institutions

68

  1. University of California San Diego

    San Diego, United States

    2 h-index

    10 publications

    357 citations

  2. University of Massachusetts Chan Medical School

    Worcester, United States

    2 h-index

    4 publications

    542 citations

  3. Max Planck Institute for Medical Research

    Heidelberg, Germany

    2 h-index

    3 publications

    39 citations

  4. Carl von Ossietzky Universität Oldenburg

    Oldenburg, Germany

    1 h-index

    3 publications

    45 citations

  5. Boğaziçi University

    Istanbul, Türkiye

    1 h-index

    3 publications

    45 citations

  6. Foundation for Applied Molecular Evolution

    Gainesville, United States

    1 h-index

    4 publications

    176 citations

  7. Université de Montréal

    Montreal, Canada

    1 h-index

    3 publications

    54 citations

  8. General Electric (Spain)

    Madrid, Spain

    1 h-index

    2 publications

    102 citations

1–8 of 68

Venues

  1. Biochemistry

    3 publications · 254 citations

    3

    h-index

  2. FEBS Letters

    2 publications · 36 citations

    2

    h-index

  3. PLoS Computational Biology

    2 publications · 254 citations

    2

    h-index

  4. Methods in molecular biology

    Book series · 1 publications · 21 citations

    1

    h-index

  5. 1

    h-index

1–5