Concepedia

Enzyme Reactivity

Enzyme Reactivity is a biochemical construct that denotes the intrinsic capacity of an enzyme to accelerate a chemical transformation through the formation of transient covalent intermediates with its substrate, distinguishing it from mere binding affinity or structural specificity by emphasizing catalytic efficiency and mechanistic participation in covalent catalysis.

199

Publications

11.7K

Citations

771

Authors

277

Institutions

Publications per year

2017–2026

30

Parents

Publications

199

An empirical valence bond approach for comparing reactions in solutions and in enzymes

Arieh Warshel, Robert M. Weiss · Journal of the American Chemical Society · 1980 · 953 citations

, , +8

Selective molecular recognition, C-H bond activation, and catalysis in nanoscale reaction \nvessels

Dorothea Fiedler, Dennis Leung, Kenneth N. Raymond et al. · eScholarship (California Digital Library) · 2004 · 944 citations

, , +17

Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations

Yutaka Sagara, Giuseppe Inesi · Journal of Biological Chemistry · 1991 · 459 citations · Full text

, , +17

Differences in the chemical reactivity of individual molecules of an enzyme

Qifeng Xue, Edward S. Yeung · Nature · 1995 · 308 citations

, , +14

High‐Accuracy Computation of Reaction Barriers in Enzymes

Frederik Claeyssens, Jeremy N. Harvey, Frederick R. Manby et al. · Angewandte Chemie International Edition · 2006 · 270 citations

, , +17

1–5 of 199

Authors

771

  1. QH
    Qian-Qian Huang

    Dalian University of Technology, China

    4 publications · 173 citations

    4

    h-index

  2. YS
    Ying‐Ji Sun

    Dalian University of Technology, China

    4 publications · 173 citations

    4

    h-index

  3. DE
    Daniel E. Koshland

    University of California, Berkeley, United States

    3 publications · 302 citations

    3

    h-index

  4. AJ
    Adrian J. Mulholland

    University of Bristol, United Kingdom

    3 publications · 369 citations

    3

    h-index

  5. JZ
    Jianjun Zhang

    Chinese Academy of Sciences, China

    3 publications · 105 citations

    3

    h-index

1–5 of 771

Institutions

277

  1. University of California, Berkeley

    Berkeley, United States

    5 h-index

    13 publications

    3.6K citations

  2. Lund University

    Lund, Sweden

    4 h-index

    7 publications

    189 citations

  3. Dalian University of Technology

    Dalian, China

    4 h-index

    11 publications

    451 citations

  4. Johns Hopkins University

    Baltimore, United States

    4 h-index

    16 publications

    1.6K citations

  5. University of Minnesota

    Minneapolis, United States

    4 h-index

    11 publications

    914 citations

  6. University of Bristol

    Bristol, United Kingdom

    3 h-index

    13 publications

    1.8K citations

  7. University of Regensburg

    Regensburg, Germany

    3 h-index

    11 publications

    2.3K citations

  8. University of California San Diego

    San Diego, United States

    3 h-index

    9 publications

    463 citations

1–8 of 277

Venues

  1. Biochemistry

    13 publications · 460 citations

    12

    h-index

  2. Journal of the American Chemical Society

    JACS · 11 publications · 1.7K citations

    11

    h-index

  3. Journal of Biological Chemistry

    JBC · 9 publications · 942 citations

    9

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 330 citations

    7

    h-index

  5. Inorganic Chemistry

    4 publications · 187 citations

    4

    h-index

1–5