Concepedia

Enzymatic Uncaging

Enzymatic Uncaging is a biochemical strategy in which an inactive molecule is selectively activated through enzyme-mediated cleavage of a protecting group, thereby distinguishing it from other activation methods by its reliance on enzymatic specificity and catalytic efficiency.

5

Publications

274

Citations

35

Authors

15

Institutions

Publications per year

2017–2026

3

Parents

Publications

5

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell

Yasunori Okamoto, Ryosuke Kojima, Fabian Schwizer et al. · Nature Communications · 2018 · 131 citations · Full text

, , +17

Design and Synthesis of A Caged Zn<sup>2+</sup> Probe, 8-Benzenesulfonyloxy-5-<i>N,N</i>-dimethylaminosulfonylquinolin-2-ylmethyl-pendant 1,4,7,10-Tetraazacyclododecane, and Its Hydrolytic Uncaging upon Complexation with Zn<sup>2+</sup>

Shin Aoki, Kazusa Sakurama, Ryosuke Ohshima et al. · Inorganic Chemistry · 2008 · 46 citations

, , +10

Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles

Elizabeth S. Levy, Demosthenes Morales, John V. Garcia et al. · Chemical Communications · 2015 · 46 citations · Full text

, , +17

Liquid Metal as Bioinspired and Unusual Modulator in Bioorthogonal Catalysis for Tumor Inhibition Therapy

Lu Zhang, Yanjuan Sang, Zhenqi Liu et al. · Angewandte Chemie International Edition · 2022 · 31 citations

, , +17

Intracellular Uncaging of cGMP with Blue Light

Hitesh K. Agarwal, Shenyu Zhai, D. James Surmeier et al. · ACS Chemical Neuroscience · 2017 · 20 citations

, , +12

1–5 of 5

Authors

35

  1. JV
    John V. Garcia

    University of California, Santa Barbara, United States

    1 publications · 46 citations

    1

    h-index

  2. HK
    Hitesh K. Agarwal

    University of Rhode Island, United States

    1 publications · 20 citations

    1

    h-index

  3. XQ
    Xiaogang Qu

    Changchun Institute of Applied Chemistry, China

    1 publications · 31 citations

    1

    h-index

  4. TH
    Tillmann Heinisch

    University of Basel, Switzerland

    1 publications · 131 citations

    1

    h-index

  5. ES
    Elizabeth S. Levy

    University of California, San Francisco, United States

    1 publications · 46 citations

    1

    h-index

1–5 of 35

Institutions

15

  1. University of Basel

    Basel, Switzerland

    1 h-index

    4 publications

    524 citations

  2. The University of Tokyo

    Tokyo, Japan

    1 h-index

    1 publications

    131 citations

  3. Changchun Institute of Applied Chemistry

    Changchun, China

    1 h-index

    9 publications

    279 citations

  4. Northwestern University

    Evanston, United States

    1 h-index

    2 publications

    40 citations

  5. Icahn School of Medicine at Mount Sinai

    New York, United States

    1 h-index

    2 publications

    40 citations

  6. Hiroshima University

    Hiroshima, Japan

    1 h-index

    9 publications

    414 citations

  7. ETH Zurich

    Zurich, Switzerland

    1 h-index

    2 publications

    262 citations

  8. University of California System

    Oakland, United States

    1 h-index

    5 publications

    230 citations

1–8 of 15

Venues

  1. ACS Chemical Neuroscience

    1 publications · 20 citations

    1

    h-index

  2. Angewandte Chemie International Edition

    1 publications · 31 citations

    1

    h-index

  3. Chemical Communications

    ChemComm · 1 publications · 46 citations

    1

    h-index

  4. Inorganic Chemistry

    1 publications · 46 citations

    1

    h-index

  5. Nature Communications

    1 publications · 131 citations

    1

    h-index

1–5