Concepedia

Entropy-enthalpy Compensation

Entropy–Enthalpy Compensation is a thermodynamic phenomenon in which changes in enthalpy and entropy during protein–ligand binding processes are linearly correlated, such that favorable gains in one are partially offset by unfavorable shifts in the other, thereby minimizing the overall change in binding free energy.

324

Publications

17.7K

Citations

1.2K

Authors

440

Institutions

Publications per year

2017–2026

61

Parents

Publications

324

Enthalpy-entropy compensation. 2. Separation of the chemical from the statistical effect

Russell R. Krug, William G. Hunter, R. A. Grieger · The Journal of Physical Chemistry · 1976 · 804 citations

, , +11

Enthalpy-entropy compensation. 1. Some fundamental statistical problems associated with the analysis of van't Hoff and Arrhenius data

Russell R. Krug, William G. Hunter, R. A. Grieger · The Journal of Physical Chemistry · 1976 · 718 citations

, , +16

Entropy—enthalpy compensation: Fact or artifact?

Kim A. Sharp · Protein Science · 2001 · 420 citations · Full text

, , +17

Thermodynamics of molecular recognition by cyclodextrins. 1. Calorimetric titration of inclusion complexation of naphthalenesulfonates with .alpha.-, .beta.-, and .gamma.-cyclodextrins: enthalpy-entropy compensation

Yoshihisa Inoue, Tadao Hakushi, Yu Liu et al. · Journal of the American Chemical Society · 1993 · 403 citations

, , +16

Solvent Reorganization and Thermodynamic Enthalpy-Entropy Compensation

Ernest Grunwald, Colin Steel · Journal of the American Chemical Society · 1995 · 368 citations

, , +12

1–5 of 324

Authors

1.2K

  1. JF
    Jack F. Douglas

    National Institute of Standards and Technology, United States

    7 publications · 262 citations

    7

    h-index

  2. FM
    Fleming Martínez

    Universidad Nacional de Colombia, Colombia

    6 publications · 320 citations

    6

    h-index

  3. TH
    Tadao Hakushi

    Himeji University, Japan

    6 publications · 652 citations

    6

    h-index

  4. DH
    Dudley H. Williams

    University of Cambridge, United Kingdom

    5 publications · 404 citations

    5

    h-index

  5. EB
    E. B. Starikov

    Freie Universität Berlin, Germany

    5 publications · 353 citations

    5

    h-index

1–5 of 1.2K

Institutions

440

  1. National Institute of Standards and Technology

    Gaithersburg, United States

    8 h-index

    15 publications

    408 citations

  2. University of Cambridge

    Cambridge, United Kingdom

    8 h-index

    25 publications

    985 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    18 publications

    905 citations

  4. Universidad Nacional de Colombia

    Bogotá, Colombia

    5 h-index

    15 publications

    507 citations

  5. Chalmers University of Technology

    Gothenburg, Sweden

    5 h-index

    8 publications

    655 citations

  6. Karlsruhe Institute of Technology

    Karlsruhe, Germany

    5 h-index

    11 publications

    1.7K citations

  7. Universidad de Alcalá

    Alcalá de Henares, Spain

    4 h-index

    8 publications

    609 citations

  8. Johns Hopkins Medicine

    Baltimore, United States

    4 h-index

    7 publications

    800 citations

1–8 of 440

Venues

  1. Biochemistry

    17 publications · 897 citations

    15

    h-index

  2. Journal of the American Chemical Society

    JACS · 15 publications · 2K citations

    14

    h-index

  3. The Journal of Physical Chemistry B

    16 publications · 692 citations

    14

    h-index

  4. Chemistry - A European Journal

    10 publications · 448 citations

    10

    h-index

  5. The Journal of Physical Chemistry

    10 publications · 2.1K citations

    10

    h-index

1–5