Concepedia

Enhancer Hierarchy

Enhancer Hierarchy is a regulatory architecture in which enhancers are organized into a ranked structure based on their functional dominance and interaction patterns, distinguishing it from simple enhancer clustering by specifying a directional and combinatorial influence on gene expression.

22

Publications

1.8K

Citations

103

Authors

50

Institutions

Publications per year

2017–2026

5

Parents

Publications

22

The SV40 enhancer contains two distinct levels of organization

Brian Ondek, Lisa M. Gloss, Winship Herr · Nature · 1988 · 282 citations

, , +10

Dissecting super-enhancer hierarchy based on chromatin interactions

Jialiang Huang, Kailong Li, Wenqing Cai et al. · Nature Communications · 2018 · 247 citations · Full text

, , +17

Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

Catherine Fromental-Ramain, Masamoto Kanno, Hisayuki Nomiyama et al. · Cell · 1988 · 240 citations

, , +12

The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes

James Gorman, Nienke van der Stoep, R. J. Monroe et al. · Immunity · 1996 · 168 citations · Full text

, , +15

Distinct factors bind to apparently homolgous sequences in the immunoglobulin heavy-chain enhancer

Judah Weinberger, David Baltimore, Phillip A. Sharp · Nature · 1986 · 160 citations

, , +9

1–5 of 22

Authors

103

  1. JH
    Jialiang Huang

    Dana-Farber Cancer Institute, United States

    3 publications · 324 citations

    3

    h-index

  2. WC
    Wenqing Cai

    Dana-Farber Cancer Institute, United States

    3 publications · 324 citations

    3

    h-index

  3. GY
    Guo‐Cheng Yuan

    Dana-Farber Cancer Institute, United States

    3 publications · 324 citations

    3

    h-index

  4. SH
    Stuart H. Orkin

    Dana-Farber Cancer Institute, United States

    3 publications · 324 citations

    3

    h-index

  5. JX
    Jian Xu

    The University of Texas Southwestern Medical Center, United States

    2 publications · 279 citations

    2

    h-index

1–5 of 103

Institutions

50

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    9 publications

    1.3K citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    15 publications

    1.4K citations

  3. Harvard University

    Cambridge, United States

    3 h-index

    11 publications

    1.3K citations

  4. Boston Children's Hospital

    Boston, United States

    2 h-index

    8 publications

    966 citations

  5. The University of Texas Southwestern Medical Center

    Dallas, United States

    2 h-index

    8 publications

    1.1K citations

  6. Children's Medical Center

    Dallas, United States

    2 h-index

    8 publications

    1.1K citations

  7. Dana-Farber/Boston Children's Cancer and Blood Disorders Center

    Boston, United States

    2 h-index

    7 publications

    561 citations

  8. Whitehead Institute for Biomedical Research

    Cambridge, United States

    2 h-index

    4 publications

    493 citations

1–8 of 50

Venues

  1. Nature

    3 publications · 553 citations

    3

    h-index

  2. Developmental Biology

    2 publications · 66 citations

    2

    h-index

  3. Molecular and Cellular Biology

    MCB · 2 publications · 59 citations

    2

    h-index

  4. Nature Communications

    2 publications · 332 citations

    2

    h-index

  5. Seminars in Virology

    1 publications · 21 citations

    1

    h-index

1–5