Concepedia

Enhancer Competition

Enhancer Competition is a regulatory genetic phenomenon in which multiple enhancer elements contend for interaction with a shared promoter or transcriptional machinery, thereby differentially influencing gene expression levels through their relative binding affinities and spatial configurations.

28

Publications

2K

Citations

94

Authors

37

Institutions

Publications per year

2017–2026

1

Variants

Promoter-enhancer Competition

Parents

Publications

28

Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.

Hengmi Cui, Patrick Onyango, Sheri A. Brandenburg et al. · PubMed · 2002 · 392 citations · Full text

, , +17

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

H Weintraub, Robert L. Davis, Daniel Lockshon et al. · Proceedings of the National Academy of Sciences · 1990 · 293 citations

, , +15

Identification of a stage selector element in the human gamma‐globin gene promoter that fosters preferential interaction with the 5′ HS2 enhancer when in competition with the beta‐promoter.

Stephen M. Jane, Paul A. Ney, Elio F. Vanin et al. · The EMBO Journal · 1992 · 141 citations · Full text

, , +17

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencer

Debora Mancini‐DiNardo · Human Molecular Genetics · 2003 · 129 citations · Full text

, , +17

Imprinting of IGF2 and H19: lack of reciprocity in sporadic Beckwith- Wiedemann syndrome

Johanna A. Joyce · Human Molecular Genetics · 1997 · 124 citations

, , +16

1–5 of 28

Authors

94

  1. QN
    Qian N. Fan

    San Diego State University, United States

    2 publications · 53 citations

    2

    h-index

  2. KA
    Kenneth A. Roebuck

    Rush University Medical Center, United States

    2 publications · 53 citations

    2

    h-index

  3. WE
    William E. Stumph

    San Diego State University, United States

    2 publications · 53 citations

    2

    h-index

  4. DM
    Debora Mancini‐DiNardo

    Myriad Genetics, United States

    2 publications · 140 citations

    2

    h-index

  5. DP
    Daniel P. Szeto

    Howard Hughes Medical Institute, United States

    2 publications · 53 citations

    2

    h-index

1–5 of 94

Institutions

37

  1. Princeton University

    Princeton, United States

    3 h-index

    5 publications

    416 citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    3 h-index

    5 publications

    416 citations

  3. National Institutes of Health

    Bethesda, United States

    2 h-index

    8 publications

    846 citations

  4. University of Pittsburgh

    Pittsburgh, United States

    2 h-index

    4 publications

    111 citations

  5. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    4 publications

    199 citations

  6. San Diego State University

    San Diego, United States

    2 h-index

    10 publications

    265 citations

  7. Dalhousie University

    Halifax, Canada

    1 h-index

    1 publications

    26 citations

  8. University of Southern California

    Los Angeles, United States

    1 h-index

    4 publications

    392 citations

1–8 of 37

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 462 citations

    5

    h-index

  2. Human Molecular Genetics

    3 publications · 264 citations

    3

    h-index

  3. Molecular and Cellular Biology

    MCB · 3 publications · 79 citations

    3

    h-index

  4. Journal of Biological Chemistry

    JBC · 3 publications · 104 citations

    3

    h-index

  5. PLoS Genetics

    2 publications · 96 citations

    2

    h-index

1–5