Concepedia

Endosomal Sensing

Endosomal Sensing is a class of innate immune recognition mechanisms in which pattern recognition receptors detect microbial nucleic acids and other pathogen-associated molecular patterns within endosomal compartments of immune cells, distinguishing it from surface or cytosolic sensing by its localization to acidified vesicular structures that facilitate ligand accessibility and receptor activation.

21

Publications

2.4K

Citations

137

Authors

61

Institutions

Publications per year

2017–2026

4

Parents

Publications

21

Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

Alenka Kužnik, Mojca Benčina, Urban Švajger et al. · The Journal of Immunology · 2011 · 610 citations · Full text

, , +13

Induction of Inflammatory Cytokines and Interferon Responses by Double-stranded and Single-stranded siRNAs is Sequence-dependent and Requires Endosomal Localization

Mouldy Sioud · Journal of Molecular Biology · 2005 · 417 citations

, , +17

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

Norihiro Nakamura, Jennie R. Lill, Qui Phung et al. · Nature · 2014 · 311 citations

, , +16

Endosomal Translocation of Vertebrate DNA Activates Dendritic Cells via TLR9-Dependent and -Independent Pathways

Kei Yasuda, Philipp Yu, Carsten J. Kirschning et al. · The Journal of Immunology · 2005 · 254 citations · Full text

, , +13

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

Amanda L. Gavin, Deli Huang, Christoph Huber et al. · Nature Immunology · 2018 · 149 citations

, , +8

1–5 of 21

Authors

137

  1. HH
    Hubertus Hochrein

    Bavarian Nordic (Germany), Germany

    3 publications · 442 citations

    3

    h-index

  2. CJ
    Carsten J. Kirschning

    Technical University of Munich, Germany

    2 publications · 281 citations

    2

    h-index

  3. LG
    Li Gu

    Jiaxing University, China

    1 publications · 26 citations

    1

    h-index

  4. RH
    R. Hwu

    Clemson University, United States

    1 publications · 40 citations

    1

    h-index

  5. NN
    Norihiro Nakamura

    The University of Osaka, Japan

    1 publications · 311 citations

    1

    h-index

1–5 of 137

Institutions

61

  1. University of Massachusetts Chan Medical School

    Worcester, United States

    2 h-index

    9 publications

    153 citations

  2. Bavarian Nordic (Germany)

    Munich, Germany

    2 h-index

    3 publications

    227 citations

  3. Swiss Federal Laboratories for Materials Science and Technology

    Dübendorf, Switzerland

    1 h-index

    1 publications

    39 citations

  4. University of Nottingham

    Nottingham, United Kingdom

    1 h-index

    3 publications

    75 citations

  5. Tokyo Metropolitan Institute of Medical Science

    Tokyo, Japan

    1 h-index

    8 publications

    384 citations

  6. University Hospital Frankfurt

    Frankfurt am Main, Germany

    1 h-index

    1 publications

    73 citations

  7. University of Messina

    Messina, Italy

    1 h-index

    7 publications

    126 citations

  8. Saudi Aramco (United States)

    Houston, United States

    1 h-index

    1 publications

    26 citations

1–8 of 61

Venues

  1. The Journal of Immunology

    JI · 6 publications · 999 citations

    6

    h-index

  2. Genes & Genomics

    1 publications · 21 citations

    1

    h-index

  3. eLife

    1 publications · 21 citations

    1

    h-index

  4. Nature Immunology

    1 publications · 149 citations

    1

    h-index

  5. Journal of Mathematical Biology

    1 publications · 25 citations

    1

    h-index

1–5