Concepedia

Dual-site Binding Models

Dual-Site Binding Models is a theoretical framework in receptor pharmacology that characterizes ligand-receptor interactions by postulating two distinct binding sites on a receptor protein, differing in affinity and functional response, to explain non-monotonic or biphasic dose-response relationships.

46

Publications

2.6K

Citations

220

Authors

102

Institutions

Publications per year

2017–2026

13

Parents

Publications

46

Two disparate ligand-binding sites in the human P2Y1 receptor

Dandan Zhang, Zhan‐Guo Gao, Kaihua Zhang et al. · Nature · 2015 · 370 citations · Full text

, , +14

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor

Christian Elling, Søren Nielsen, Thue W. Schwartz · Nature · 1995 · 168 citations

, , +12

Plasmodium sporozoite invasion into insect and mammalian cells is directed by the same dual binding system

Kai Matuschewski, Álvaro Cantini Nunes, Victor Nussenzweig et al. · The EMBO Journal · 2002 · 167 citations · Full text

, , +14

Evaluation of short-tether Bis-THA AChE inhibitors. A further test of the dual binding site hypothesis

Paul R. Carlier, Yifan Han, Ella S.‐H. Chow et al. · Bioorganic & Medicinal Chemistry · 1999 · 158 citations · Full text

, , +15

Drug-protein interactions: Two-site binding of heterocyclic ligands to a monomeric hemoglobin

Joseph J. Stephanos · Journal of Inorganic Biochemistry · 1996 · 151 citations

, , +17

1–5 of 46

Authors

220

  1. RB
    Ritu Barthwal

    Indian Institute of Technology Roorkee, India

    3 publications · 68 citations

    3

    h-index

  2. WD
    Wayne D. Bowen

    National Institutes of Health, United States

    2 publications · 200 citations

    2

    h-index

  3. RB
    Richard B. Rothman

    National Institute on Drug Abuse, United States

    2 publications · 70 citations

    2

    h-index

  4. AE
    Arthur E. Jacobson

    National Institutes of Health, United States

    2 publications · 70 citations

    2

    h-index

  5. PR
    Paul R. Carlier

    Virginia Tech, United States

    2 publications · 190 citations

    2

    h-index

1–5 of 220

Institutions

102

  1. Indian Institute of Technology Roorkee

    Roorkee, India

    4 h-index

    7 publications

    187 citations

  2. Mayo Clinic

    Rochester, United States

    3 h-index

    4 publications

    338 citations

  3. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    20 publications

    3.8K citations

  4. Beijing National Laboratory for Molecular Sciences

    Beijing, China

    2 h-index

    10 publications

    114 citations

  5. State Key Laboratory for Structural Chemistry of Unstable and Stable Species

    Beijing, China

    2 h-index

    11 publications

    138 citations

  6. Hong Kong University of Science and Technology

    Hong Kong, Hong Kong

    2 h-index

    12 publications

    1.3K citations

  7. Brown University

    Providence, United States

    2 h-index

    2 publications

    200 citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    4 publications

    372 citations

1–8 of 102

Venues

  1. Journal of Biological Chemistry

    JBC · 3 publications · 129 citations

    3

    h-index

  2. Biochimie

    3 publications · 68 citations

    3

    h-index

  3. Bioorganic & Medicinal Chemistry

    2 publications · 190 citations

    2

    h-index

  4. Neuropeptides

    2 publications · 70 citations

    2

    h-index

  5. Structure

    2 publications · 48 citations

    2

    h-index

1–5