Concepedia

Drug Development Endpoints

Drug Development Endpoints is a type of clinical trial outcome measure that specifically quantifies the therapeutic effect or safety profile of a drug candidate, distinguishing it from surrogate or intermediate markers by directly reflecting meaningful clinical benefits relevant to patient health and regulatory approval decisions.

17

Publications

3.3K

Citations

83

Authors

57

Institutions

Publications per year

2017–2026

7

Parents

Publications

17

Clinical development success rates for investigational drugs

Michael Hay, David W. Thomas, John L. Craighead et al. · Nature Biotechnology · 2014 · 2.5K citations

, , +12

Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity

Valsamo Anagnostou, Mark Yarchoan, Aaron R. Hansen et al. · Clinical Cancer Research · 2017 · 181 citations · Full text

, , +17

High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell–Derived Cells

Oksana Sirenko, Jayne Hesley, Ivan Rusyn et al. · Assay and Drug Development Technologies · 2013 · 120 citations · Full text

, , +17

Accurate clinical toxicity prediction using multi-task deep neural nets and contrastive molecular explanations

Bhanushee Sharma, Vijil Chenthamarakshan, Amit Dhurandhar et al. · Scientific Reports · 2023 · 101 citations · Full text

, , +14

Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development

RV Overgaard, SH Ingwersen, CW Tornøe · CPT Pharmacometrics & Systems Pharmacology · 2015 · 97 citations · Full text

, , +12

1–5 of 17

Authors

83

  1. AD
    Amit Dhurandhar

    IBM (United States), United States

    2 publications · 112 citations

    2

    h-index

  2. PD
    Payel Das

    IBM Research - Thomas J. Watson Research Center, United States

    2 publications · 112 citations

    2

    h-index

  3. BS
    Bhanushee Sharma

    Mount Holyoke College, United States

    2 publications · 112 citations

    2

    h-index

  4. JH
    James Hendler

    University of Maryland, College Park, United States

    2 publications · 112 citations

    2

    h-index

  5. VC
    Vijil Chenthamarakshan

    IBM (United States), United States

    2 publications · 112 citations

    2

    h-index

1–5 of 83

Institutions

57

  1. Johns Hopkins University

    Baltimore, United States

    1 h-index

    5 publications

    905 citations

  2. Novartis (Switzerland)

    Basel, Switzerland

    1 h-index

    1 publications

    35 citations

  3. Advocates for Youth

    Washington D.C., United States

    1 h-index

    1 publications

    181 citations

  4. European Organisation for Research and Treatment of Cancer

    Amsterdam, Netherlands

    1 h-index

    1 publications

    18 citations

  5. Institute for Biomedicine

    Bolzano, Italy

    1 h-index

    2 publications

    5K citations

  6. Emory University

    Atlanta, United States

    1 h-index

    1 publications

    20 citations

  7. Western Infirmary

    Glasgow, United Kingdom

    1 h-index

    1 publications

    18 citations

  8. Houston Methodist

    Houston, United States

    1 h-index

    1 publications

    20 citations

1–8 of 57

Venues

  1. American Journal of Transplantation

    2 publications · 57 citations

    2

    h-index

  2. Drug Discovery Today

    2 publications · 54 citations

    2

    h-index

  3. Journal of Translational Medicine

    JTM · 1 publications · 44 citations

    1

    h-index

  4. The AAPS Journal

    AAPSJ · 1 publications · 79 citations

    1

    h-index

  5. Clinical Cancer Research

    1 publications · 181 citations

    1

    h-index

1–5