Concepedia

Dose-exposure-response Modeling

Dose-Exposure-Response Modeling is a population pharmacokinetic-pharmacodynamic framework that integrates the administered dose, the resulting drug concentration in the body (exposure), and the measured pharmacological effect (response) to quantitatively describe and predict the temporal and magnitude relationships among these three elements in a given population.

32

Publications

1.1K

Citations

210

Authors

91

Institutions

Publications per year

2017–2026

17

Variants

Poppk/pd Modeling

Parents

Publications

32

Evaluation of ozone exposure indices in exposure-response modeling

E.Henry Lee, David T. Tingey, William E. Hogsett · Environmental Pollution · 1988 · 136 citations

, , +13

Population modelling in drug development

Lewis B. Sheiner, Jon Wakefield · Statistical Methods in Medical Research · 1999 · 94 citations

, , +17

Physiologically-based pharmacokinetic modelling of immune, reproductive and carcinogenic effects from contaminant exposure in polar bears (Ursus maritimus) across the Arctic

Runé Dietz, Kim Gustavson, Christian Sonne et al. · Environmental Research · 2015 · 87 citations

, , +17

Clinical pharmacokinetics of tumor necrosis factor antagonists.

Ivan Nestorov · PubMed · 2005 · 74 citations

, , +13

Advancements in Life Cycle Human Exposure and Toxicity Characterization

Peter Fantke, Lesa L. Aylward, Jane Bare et al. · Environmental Health Perspectives · 2018 · 60 citations · Full text

, , +17

1–5 of 32

Authors

210

  1. MV
    Martijn van Noort

    Netherlands Organisation for Applied Scientific Research, Netherlands

    2 publications · 37 citations

    2

    h-index

  2. JL
    Jörg Lippert

    Bayer (Germany), Germany

    2 publications · 37 citations

    2

    h-index

  3. HJ
    Hiddo J.L. Heerspink

    University Medical Center Groningen, Netherlands

    2 publications · 37 citations

    2

    h-index

  4. NS
    Nelleke Snelder

    Bayer (Germany), Germany

    2 publications · 37 citations

    2

    h-index

  5. SC
    Sebastiaan C. Goulooze

    Centre for Human Drug Research, Netherlands

    2 publications · 37 citations

    2

    h-index

1–5 of 210

Institutions

91

  1. University Medical Center Groningen

    Groningen, The Netherlands

    2 h-index

    2 publications

    37 citations

  2. University of Groningen

    Groningen, The Netherlands

    2 h-index

    2 publications

    37 citations

  3. Daiichi-Sankyo (Japan)

    Tokyo, Japan

    2 h-index

    4 publications

    130 citations

  4. Environmental Protection Agency

    Washington, United States

    2 h-index

    7 publications

    572 citations

  5. Bayer (Germany)

    Leverkusen, Germany

    2 h-index

    6 publications

    106 citations

  6. Gradient (United States)

    Boston, United States

    2 h-index

    3 publications

    130 citations

  7. GlaxoSmithKline (United States)

    Philadelphia, United States

    1 h-index

    4 publications

    100 citations

  8. Silent Spring Institute

    Newton, United States

    1 h-index

    1 publications

    60 citations

1–8 of 91

Venues

  1. CPT Pharmacometrics & Systems Pharmacology

    PSP · 4 publications · 75 citations

    4

    h-index

  2. Statistical Methods in Medical Research

    2 publications · 119 citations

    2

    h-index

  3. Clinical Pharmacokinetics

    2 publications · 57 citations

    2

    h-index

  4. Clinical Therapeutics

    2 publications · 47 citations

    2

    h-index

  5. Regulatory Toxicology and Pharmacology

    RTP · 2 publications · 41 citations

    2

    h-index

1–5